动物前庭功能的评价方法

发布时间：2018-02-08 22:14

本文关键词： 实验动物前庭功能检测前庭功能障碍　出处：《中华耳科学杂志》2016年06期 　论文类型：期刊论文

【摘要】：前庭神经系统障碍可导致人和动物空间定向和平衡功能的紊乱;前庭是内耳的重要组成部分,其起源与耳蜗相同,发育早于耳蜗,哺乳动物出生时前庭发育基本完成~([1-3]);随着各种前庭功能障碍的动物模型(大鼠"异食癖"晕动病模型、水貂呕吐模型等)不断建立,人们对该系统组织结构、功能的认识更加深入;系统的动物前庭功能评价方法不仅对动物前庭的基础研究至关重要,而且有助于对临床上前庭疾病的诊疗。评价人前庭功能的方法有很多:对半规管功能进行检测的冷热试验检查、对球囊斑功能进行检测的c VEMP、对椭圆囊斑进行检测的o VEMP等,由于人的实验研究受制于伦理学的限制,只有进行动物实验才能更深入地了解前庭的功能和结构,不断提升前庭系统临床疾病的诊断与治疗水平~([4])。本综述主要介绍几种用于实验动物的前庭检查方法,并简述其与临床前庭功能检查的异同。
[Abstract]:Disorders of the vestibular nervous system can lead to the disorder of spatial orientation and balance in humans and animals; vestibule is an important component of the inner ear, having the same origin as the cochlea and developing earlier than the cochlea. The vestibular development of mammals was basically completed at birth ([1-3]). With the establishment of animal models of vestibular dysfunction (rat "transvestivism" motion sickness model, mink vomiting model, etc.), the structure of the system was studied. The systematic evaluation method of animal vestibular function is important not only for the basic research of animal vestibule, but also for the basic research of animal vestibule. There are many methods to evaluate the vestibular function of human, such as cold and hot test for semicircular canal function, c-VEMPfor the function of balloon plaque, and o VEMP for detecting elliptical plaque, etc. Because human experimental research is restricted by ethics, only animal experiments can better understand the function and structure of vestibule. To improve the level of diagnosis and treatment of vestibular system clinical diseases. This review mainly introduces several vestibular examination methods used in laboratory animals and briefly describes the similarities and differences between them and clinical vestibular function examination.
【作者单位】：徐州医学院听力中心;徐州医学院附属医院临床听力中心;中国人民解放军总医院耳鼻咽喉头颈外科;
【基金】：国家973计划重大科学研究计划干细胞项目(2012CB967900) 国家973计划重大科学问题导向项目(2011CBA01000) 国家自然科学基金青年项目(81400472)
【分类号】：R764

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