人喉鳞状细胞癌中CMIP的表达及意义

发布时间：2018-02-11 16:04

本文关键词： 喉肿瘤鳞状细胞癌 CMIP 实时荧光定量PCR 免疫组织化学　出处：《临床与实验病理学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨CMIP(C-Maf inducing protein)基因在人喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)和喉息肉组织中的表达及其临床意义。方法应用实时荧光定量PCR法检测28例人LSCC和23例喉息肉组织中CMIP mRNA的表达;应用免疫组化法检测86例人LSCC和29例喉息肉组织中CMIP蛋白的表达,分析其与LSCC临床病理特征及其预后的关系。结果 LSCC CMIP mRNA和蛋白表达均显著高于喉息肉组织;CMIP表达与LSCC淋巴结转移和临床分期呈显著正相关,并且CMIP表达均与LSCC患者无复发生存期(relapse-free survival,RFS)和总生存期(overall survival,OS)密切相关。结论 CMIP可能参与人LSCC的发生、发展,CMIP表达提高可能是LSCC进展和预后不良的潜在标志物。
[Abstract]:Objective to investigate the expression and clinical significance of CMIP(C-Maf inducing protein gene in laryngeal squamous cell carcinoma (LSCC) and laryngeal polyps. Methods the expression of CMIP mRNA was detected in 28 cases of human LSCC and 23 cases of laryngeal polyps by real-time fluorescence quantitative PCR. The expression of CMIP protein in 86 cases of human LSCC and 29 cases of laryngeal polyps was detected by immunohistochemistry. Results the expression of LSCC CMIP mRNA and protein was significantly higher than that in laryngeal polyp tissues and had a significant positive correlation with LSCC lymph node metastasis and clinical stage. Moreover, the expression of CMIP was closely related to the recurrence free survival time (RFS) and the total survival time (TFS) in LSCC patients. Conclusion CMIP may be involved in the occurrence of LSCC, and the increased expression of LSCC may be a potential marker for the progression and poor prognosis of LSCC.
【作者单位】：安徽医科大学病理学教研室;安徽省阜阳市太和县中医院耳鼻喉科;安徽医科大学第一附属医院耳鼻喉科;
【基金】：安徽省学术和技术带头人及后备人选科研基金资助项目(2016H074) 安徽省高校优秀青年人才支持计划重点项目(gxyq ZD2016046)
【分类号】：R739.65

【相似文献】