粉尘螨滴剂舌下含服治疗变应性鼻炎124例临床效果观察

发布时间：2018-02-21 15:28

本文关键词： 变应性鼻炎免疫治疗粉尘螨滴剂舌下含服　出处：《临床合理用药杂志》2016年35期 　论文类型：期刊论文

【摘要】：目的观察舌下含服粉尘螨滴剂治疗变应性鼻炎的疗效及安全性。方法将124例尘螨过敏为主的变应性鼻炎患者,随机分为舌下含服免疫治疗(SLIT)+药物的观察组和单纯药物应用对照组,每组62例。前者以标准化粉尘螨滴剂舌下含服免疫治疗,严重时辅以对症药物治疗;对照组以糠酸莫米松鼻喷剂及孟鲁斯特对症治疗。2组患者每月回访1次,最少随访半年。观察并记录治疗后症状得分、药物评分及不良反应情况。半年后综合评价患者主观症状、用药及治疗满意度情况。结果观察组与对照组比较,其半年后症状得分、药物评分、满意度均明显高于对照组,差异均有统计学意义(P0.05)。2组均有部分患者出现了一定程度的不良反应。结论舌下含服粉尘螨滴剂治疗对尘螨过敏的变应性鼻炎患者,症状改善较为明显,但变应性鼻炎是一种慢性疾病,为确保疗效,需对治疗过程加以管理,提高依从性,对治疗中的不良反应给予关注。
[Abstract]:Objective to observe the efficacy and safety of sublingual dust mites drops in the treatment of allergic rhinitis. Methods 124 patients with allergic rhinitis were treated with dust mite hypersensitivity. The patients were randomly divided into two groups: the observation group with sublingual immunotherapy and the control group with single drug application. The former received sublingual sublingual immunotherapy with standardized dust mites drops, and in severe cases they were treated with symptomatic drugs. The patients in the control group were treated with momethasone furoate nasal spray and Menluster for symptomatic treatment once a month and followed up for at least half a year. The symptom scores after treatment were observed and recorded. Six months later, the patients' subjective symptoms, drug use and treatment satisfaction were evaluated. Results compared with the control group, the symptom scores, drug scores and satisfaction of the observation group were significantly higher than those of the control group half a year later. There were some adverse reactions in some patients in P0.052.Conclusion the symptoms of allergic rhinitis with dust mite hypersensitivity treated with sublingual dust mites drops are obviously improved. But allergic rhinitis is a chronic disease. In order to ensure the curative effect, it is necessary to manage the treatment process, improve compliance and pay attention to the adverse reactions in the treatment.
【作者单位】：浙江省绍兴市中心医院;
【分类号】：R765.21

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