血清Apelin水平监测在糖尿病视网膜病变诊断中的意义

发布时间：2018-02-24 08:26

本文关键词： 糖尿病视网膜病变 Apelin 病情诊断　出处：《广东医学》2016年18期 　论文类型：期刊论文

【摘要】：目的探讨血清Apelin水平监测在糖尿病视网膜病变(DR)患者病情诊断中的意义。方法选取2型糖尿病并发DR患者136例,将患者分为非增生型DR组(n=61)和增生型DR组(n=75),同期,选取2型糖尿病患者45例,检测血糖、血脂指标,利用酶联免疫吸附试验(ELISA法)检测血清中Apelin水平,多因素logistic回归分析分析影响DR病程的相关因素,利用受试者工作特征曲线(ROC曲线)评估Apelin在判定DR病程进展中的价值。结果增生型DR组Hb A1C、TG、TC、LDL-C、HDL-C和Apelin均高于非增生型DR组和2型糖尿病,且非增生型DR组高于2型糖尿病,差异均有统计学意义(P0.05);Pearson相关分析显示,患者血清Apelin水平与糖尿病病程、TG、TC、Hb A1C和LDL-C均呈正相关(r=0.382、0.617、0.597、0.483和0.415,P0.05),而与HDL-C呈负相关(r=-0.436,P0.05);多因素logistic回归分析显示,消除变量间共线性后,糖尿病病程、Hb A1C、LDLC、HDL-C和Apelin均是DR病程的相关影响因素(P0.05);ROC曲线分析显示,Apelin在判定DR病程进展中曲线下面积0.872(95%CI:0.813~0.930),灵敏度80.0%,特异度82.0%。结论 DR患者血清Apelin水平升高,且与患者病程、糖脂代谢异常有关,可作为评估DR患者病情进展的指标。
[Abstract]:Objective to investigate the significance of serum Apelin monitoring in the diagnosis of diabetic retinopathy. Methods 136 patients with type 2 diabetes complicated with Dr were divided into two groups: non proliferative Dr group (n = 61) and proliferative type Dr group (n = 75). Blood glucose and blood lipids were measured in 45 patients with type 2 diabetes mellitus. Serum Apelin levels were detected by Elisa. Multivariate logistic regression analysis was used to analyze the related factors affecting the course of Dr. Results the HDL-C and Apelin in the hyperplastic Dr group were higher than those in the non-proliferative Dr group and type 2 diabetes mellitus, and that in the non-proliferative Dr group was higher than that in the non-proliferative Dr group, and that in the non-proliferative Dr group was higher than that in the non-proliferative Dr group. The results of Pearson correlation analysis showed that the serum Apelin level was positively correlated with LDL-C and TGG, 0.382, 0.617, 0.597, 0.483 and 0.415, respectively, but negatively correlated with HDL-C, r-0.436P0.05. the multivariate logistic regression analysis showed that there was a positive correlation between TGG and HbA1C and LDL-C, but a negative correlation was found with HDL-C, and the results of multivariate logistic regression analysis showed that there was no linear relationship between TGG and HbA1C. HDL-C and Apelin are related factors in the course of diabetes. The analysis of P0.05 / ROC curve shows that Apelin has an area of 0.87295CIW 0.81395 CIW 0.930, sensitivity 80.0 and specificity 82.00.Conclusion the level of serum Apelin in Dr patients is increased, and it is associated with the course of disease. Abnormal glucose and lipid metabolism may be used as an index to evaluate the progression of Dr patients.
【作者单位】：河南省平顶山市第二人民医院眼科;
【基金】：河南省2014年科技发展计划项目(编号:142102310429)
【分类号】：R587.2;R774.1

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