血清salusins水平与阻塞性睡眠呼吸暂停低通气综合征高血压患者的临床分析

发布时间：2018-02-24 11:47

本文关键词： 睡眠呼吸暂停阻塞性高血压 salusin-α salusin-β　出处：《中国循环杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的:探讨血清salusins水平在原发性高血压(EH)、阻塞性睡眠呼吸暂停低通气综合征(OSAHS)以及OSAHS并发EH患者中的变化及意义。方法:选择OSAHS并发EH患者50例,设为EH+OSAHS组,同期住院治疗的单纯EH患者60例为EH组、OSAHS患者35例为OSAHS组,同期体检中心健康体检者31例为对照组。检测并记录入选者血压、睡眠呼吸暂停低通气指数(AHI)、身高、体重以及常规生化结果;应用酶联免疫吸附法(ELISA)检测血清salusin-α及salusin-β水平。多元Logistic回归分析评价各变量与OSAHS并发EH的相关性。结果:(1)血清salusin-α水平在对照组(7.438±1.626)pg/ml、OSAHS组(6.186±1.200)pg/ml、EH组(5.938±1.287)pg/ml、EH+OSAHS组(5.299±1.398)pg/ml中逐渐降低,除OSAHS组与EH组差异无统计学意义外(P0.05),其余组间两两比较差异均有统计学意义(P均0.01);(2)血清salusin-β水平在对照组(10.575±1.791)pg/ml、OSAHS组(10.279±0.530)pg/ml、EH组(9.698±0.344)pg/ml、EH+OSAHS组(9.070±0.586)pg/ml水平依次降低;OSAHS组与对照组及EH组间比较差异均无统计学意义(P均0.05);(3)多元Logistic回归分析结果显示,血清salusin-α水平与OSAHS并发EH呈独立负相关[比值比(OR)=-0.736,P0.05];血清salusin-β水平与OSAHS并发EH呈独立负相关(OR=-0.731,P0.05)。结论:低血清salusin-α水平、salusin-β水平与OSAHS并发EH相关。
[Abstract]:Objective: to investigate the changes and significance of serum salusins levels in patients with essential hypertension (EH), obstructive sleep apnea hypopnea syndrome (OSAHS) and OSAHS complicated with EH. Methods: 50 patients with OSAHS complicated with EH were selected as EH OSAHS group. In the same period, 60 patients with simple EH in EH group, 35 patients with OSAHS in EH group and 31 healthy persons in physical examination center as control group. Blood pressure, sleep apnea hypopnea index and height were measured and recorded. Body weight and routine biochemical results; The serum levels of salusin- 伪 and salusin- 尾 were detected by Elisa. The correlation between the variables and EH in OSAHS was evaluated by multivariate Logistic regression analysis. Results the serum salusin- 伪 level was decreased gradually in the control group (7.438 卤1.626 mg / ml) in 6.186 卤1.200 PG / ml EH group (5.938 卤1.287pg / ml EH OSAHS 5.299 卤1.398pg / ml). The serum salusin- 尾 level was significantly lower in the control group (10.575 卤1.791g / ml) than in the control group (10.279 卤0.530pggmlEH, 9.698 卤0.344pggml / ml EH, 9.070 卤0.586pgggml / ml). The results of multivariate Logistic regression analysis showed that there was no significant difference between the two groups. Serum salusin- 伪 level was negatively correlated with OSAHS complicated with EH (P 0.05), and serum salusin- 尾 level was negatively correlated with OSAHS complicated EH (P 0.05). Conclusion: low serum salusin- 伪 level and salusin- 尾 level are correlated with OSAHS complicated with EH.
【作者单位】：成都军区昆明总医院心血管内科;成都军区昆明总医院耳鼻咽喉颌面外科;
【分类号】：R766;R544.1

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