胎盘多肽注射液联合化疗治疗下咽癌的疗效观察

发布时间：2018-02-25 08:46

本文关键词： 下咽肿瘤胎盘提取物肽类化疗治疗结果　出处：《解放军医药杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的探讨胎盘多肽注射液联合化疗治疗下咽癌的效果。方法选择2010年8月—2012年8月收治的下咽癌37例,根据有无使用胎盘多肽注射液分为观察组20例和对照组17例。对照组给予单纯化疗治疗,观察组在对照组基础上给予胎盘多肽注射液,均治疗3个周期。评估两组临床疗效及化疗毒副反应,检测T淋巴细胞和自然杀伤(NK)细胞、鳞状细胞癌相关性抗原(SCCAg)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、角化素蛋白片段19(CYFRA21-1),评估患者功能状态及生活质量;记录1、3年存活率。结果两组总有效率及1、3年生存率比较差异无统计学意义(P0.05);观察组治疗后CD4+、CD4+/CD8+、NK细胞较治疗前和对照组升高,对照组治疗后较治疗前下降(P0.05);两组治疗后SCCAg、CEA、CA19-9、CYFRA21-1均较治疗前下降,且观察组低于对照组(P0.05);两组治疗后功能状态评分高于治疗前,生活质量调查问卷评分低于治疗前,且观察组改善情况优于对照组(P0.05)。观察组消化道反应、白细胞下降、血小板下降发生率低于对照组(P0.05)。结论胎盘多肽注射液联合化疗治疗下咽癌可改善机体免疫功能,降低血清肿瘤标志物水平,提高化疗耐受性。
[Abstract]:Objective to investigate the effect of placental polypeptide injection combined with chemotherapy on hypopharyngeal carcinoma. Methods 37 cases of hypopharyngeal carcinoma were treated from August 2010 to August 2012. According to whether placental polypeptide injection was used or not, it was divided into observation group (n = 20) and control group (n = 17). The control group was treated with chemotherapy alone and the observation group was given placental polypeptide injection on the basis of the control group. All patients were treated for 3 cycles. The clinical efficacy and side effects of chemotherapy were evaluated, T lymphocytes and natural killer NK cells were detected. Squamous cell carcinoma-associated antigen (SCCAG), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and keratin protein fragment (CYFRA21-1) were used to evaluate the functional status and quality of life (QOL) of the patients. Results there was no significant difference in the total effective rate and 1- and 3-year survival rate between the two groups (P 0.05). The CD4 / CD8 + NK cells of the observation group were higher than those of the control group after treatment. In the control group, the level of P0.05 was decreased after treatment, and the level of SCCAgCE-CA19-9 CYFRA21-1 was lower in the observation group than that in the control group after treatment, and the score of functional status was higher than that before treatment, and the score of QOL questionnaire was lower than that before treatment. The improvement in the observation group was better than that in the control group (P 0.05). The incidence of gastrointestinal reaction, leukopenia and thrombocytopenia in the observation group was lower than that in the control group. Conclusion placental polypeptide injection combined with chemotherapy can improve the immune function of patients with hypopharyngeal carcinoma. To reduce serum tumor markers and improve chemotherapeutic tolerance.
【作者单位】：河北医科大学第四医院耳鼻咽喉头颈外科;
【分类号】：R739.63

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