羟苯磺酸钙联合复方血栓通胶囊治疗早期糖尿病性视网膜病变的疗效及对血清IGF-1和VEGF水平的影响

发布时间：2018-02-26 09:30

本文关键词： 复方血栓通胶囊羟苯磺酸钙糖尿病性视网膜病变血管内皮细胞生长因子胰岛素样生长因子-　出处：《中国老年学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的探讨羟苯磺酸钙联合复方血栓通胶囊治疗早期糖尿病性视网膜病变(DR)患者的疗效及对血清中胰岛素样生长因子(IGF)-1和血管内皮细胞生长因子(VEGF)水平的影响。方法 DR患者68例,按照随机数字表法分为对照组和研究组各34例,对照组给予羟苯磺酸钙治疗,研究组给予羟苯磺酸钙联合复方血栓通胶囊治疗,两组均治疗3个月。对比两组治疗3个月后的临床总有效率,对比治疗前、治疗3个月后两组出血斑点面积、黄斑厚度、视野灰度值、微血管瘤数量、VEGF、IGF-1、舒张末期血流速度(EDV)及收缩期峰值血流速度(PSV)。结果治疗3个月后研究组临床总有效率显著高于对照组(P0.05)。治疗3个月后两组出血斑点面积、黄斑厚度、视野灰度值、微血管瘤数量、VEGF和IGF-1较治疗前均显著降低,且研究组低于对照组,EDV和PSV显著升高,且研究组高于对照组(均P0.05)。结论与单用羟苯磺酸钙治疗早期DR相比,羟苯磺酸钙联合复方血栓通胶囊治疗具有更好的临床疗效,可以更明显地降低患者出血斑点面积、黄斑厚度、视野灰度值、微血管瘤数量及VEGF、IGF-1水平,并提高EDV和PSV。
[Abstract]:Objective to investigate the efficacy of calcium dobesilate combined with compound Xuetong capsule in the treatment of patients with early diabetic retinopathy (DRR) and its effect on the levels of insulin-like growth factor (IGF-1) and vascular endothelial growth factor (VEGF) in serum. There were 68 patients with Dr. According to the method of random number table, the control group (n = 34) and the study group (n = 34) were divided into control group and study group respectively. The total effective rate of the two groups was compared after 3 months of treatment, and the hemorrhage spot area, macular thickness, visual field gray value of the two groups were compared before and after 3 months of treatment. Results after 3 months of treatment, the total effective rate of the study group was significantly higher than that of the control group (P 0.05). After 3 months of treatment, the bleeding spot area and macular thickness in the two groups were significantly higher than those in the control group. The visual field gray value, the number of microhemangioma and IGF-1 were significantly lower in the study group than those in the control group, and were significantly higher in the study group than in the control group (P 0.05). Conclusion compared with calcium dobesilate alone, the number of IGF-1 and IGF-1 in the study group was significantly higher than that in the control group (P 0.05). Calcium dobesilate combined with compound Xueshuantong capsule has better clinical efficacy, and can significantly reduce the area of bleeding spots, macular thickness, visual field gray value, the number of microhemangiomas and the level of VEGFIGF-1, and increase the levels of EDV and PSV.
【作者单位】：大庆龙南医院齐齐哈尔医学院附属第五医院眼科;
【分类号】：R587.2;R774.1

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