布拉氏酵母菌联合盐酸左西替利嗪治疗小儿变应性鼻炎的疗效观察

发布时间：2018-02-26 15:34

本文关键词： 布拉氏酵母菌盐酸左西替利嗪鼻炎变应性细胞因子儿童　出处：《临床耳鼻咽喉头颈外科杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的:探讨布拉氏酵母菌联合盐酸左西替利嗪治疗小儿变应性鼻炎(AR)的临床疗效及对血清干扰素-γ(IFN-γ)和IL-4水平的影响。方法 :90例患儿随机分为观察组与对照组,每组45例,对照组用盐酸左西替利嗪滴剂(2~6岁,5ml/次;6岁,10ml/次;1次/d,口服)。观察组在对照组基础上联合布拉氏酵母菌(3岁,0.25g/次,1次/d;3岁,0.25g/次,2次/d,口服)。4周为1个疗程,并设30例为健康组。结果:2组治疗前血清IFN-γ水平明显低于健康组(P0.01),而IL-4水平明显高于健康组(P0.01);治疗后2组均有不同程度的上调IFN-γ及下调IL-4的水平,但以治疗组的作用更明显(P0.01)。观察组临床总有效率为91.11%,明显高于对照组的68.89%(χ2=6.94,P0.01)。治疗后,2组患儿各项症状积分均较治疗前降低,但观察组明显低于对照组(P0.01)。治疗后组间比较,观察组明显优于对照组(P0.01)。结论:布拉氏酵母菌联合盐酸左西替利嗪口服溶液治疗小儿AR有明显的临床疗效,其作用机制可能与纠正紊乱的IFN-γ与IL-4有关。
[Abstract]:Objective: to investigate the clinical effect of Saccharomyces Brassicus combined with levosirizine hydrochloride in the treatment of allergic rhinitis in children and its effect on serum interferon- 纬 (IFN- 纬) and IL-4 levels. Methods: one hundred and ninety children were randomly divided into two groups: observation group (n = 45) and control group (n = 45). The control group was treated with levo-cetirizine hydrochloride drop of 5 ml / time 6 years old or 10 ml / d once a day. The observation group was treated with 0.25g / d of Saccharomyces brassicum at the age of 3 years and 0.25g / time for 2 / d, and was given a course of treatment for a period of 4 weeks, and the control group was given a course of treatment for a period of 4 weeks, and the control group was given a dose of 0.25g / d + 0.25g / time, and the control group was given a course of treatment for a period of 4 weeks. Results the level of serum IFN- 纬 was significantly lower than that of healthy group before treatment, while the level of IL-4 was significantly higher than that of healthy group P0.01.After treatment, the levels of IFN- 纬 and down-regulation of IL-4 were up-regulated and down-regulated in both groups. However, the effect of the treatment group was more obvious than that of the control group (P 0.01). The total clinical effective rate of the observation group was 91.11, which was significantly higher than that of the control group (68.89g / kg, 蠂 2 = 6.94, P 0.01). After treatment, the symptom scores of the two groups were lower than those of the control group (P 0.01), but that of the observation group was significantly lower than that of the control group (P 0.01). Conclusion: the observation group is superior to the control group (P 0.01). Conclusion: the treatment of infantile AR with Saccharomyces Brassicus combined with levatirizine hydrochloride has obvious clinical effect, and its mechanism may be related to correcting the disorder of IFN- 纬 and IL-4.
【作者单位】：金华市妇幼保健院儿科;金华职业技术学院医学院儿科;
【分类号】：R765.21

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