鼻腔鼻窦鳞状细胞癌细胞中PRL-3表达的临床意义

发布时间：2018-03-01 12:23

本文关键词： 鼻腔鼻窦癌鳞状细胞促肝细胞再生磷酸酶-　出处：《重庆医学》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨促肝细胞再生磷酸酶-3(PRL-3)在鼻腔鼻窦鳞状细胞癌(SNSCC)中表达的临床意义。方法采用免疫组织化学及逆转录PCR(RT-PCR)方法检测62例SNSCC组织(SNSCC组)中PRL-3蛋白的表达水平,并对30例鼻息肉患者(NP组),以及25例正常鼻腔黏膜(对照组)做相同蛋白表达并进行对比。结果在蛋白水平和基因水平检测,均发现SNSCC组中PRL-3的表达高于NP组及对照组,差异有统计学意义(P0.05)。PRL-3的表达情况在不同的性别、年龄中差异无统计学意义(P0.05),而随着TNM分期的增高,分化程度的降低及合并淋巴结转移,PRL-3的表达明显增高(P0.05)。结论 PRL-3的表达可以对SNSCC的增殖活性作很好的参照,表达强度可明显反映SNSCC细胞增殖活性,PRL-3可能是SNSCC的一个独立预后指标,提示预后不良。
[Abstract]:Objective to investigate the clinical significance of hepatocyte regeneration promoting phosphatase (PRL-3) expression in squamous cell carcinoma of nasal cavity and paranasal sinuses (SNSCC). Methods the expression of PRL-3 protein in 62 patients with SNSCC was detected by immunohistochemistry and reverse transcription PCRRT-PCR. The expression of the same protein in 30 cases of nasal polyps in NP group and 25 cases of normal nasal mucosa (control group) was compared. Results the expression of PRL-3 in SNSCC group was higher than that in NP group and control group. The difference was statistically significant in the expression of P0.05, PRL-3 in different sex, but not in age, but with the increase of TNM stage. The level of differentiation and the expression of PRL-3 in lymph node metastasis were significantly increased. Conclusion the expression of PRL-3 may be a good reference for the proliferative activity of SNSCC. The expression intensity of PRL-3 may be an independent prognostic marker of SNSCC, suggesting poor prognosis.
【作者单位】：承德医学院附属医院耳鼻咽喉科;承德医学院附属医院体检科;
【基金】：承德市科学技术研究与发展计划项目(201601A047)
【分类号】：R739.62

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