血清内脏脂肪素和肿瘤坏死因子α与老年2型糖尿病患者白内障的关系

发布时间：2018-03-02 06:00

本文关键词： 内脏脂肪素肿瘤坏死因子-α 老年白内障型糖尿病　出处：《临床眼科杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的观察和分析血清内脏脂肪素(visfatin)和肿瘤坏死因子α(TNF-α)与老年2型糖尿病(T2DM)患者白内障的关系。方法选取154例老年T2DM合并白内障患者,根据其白内障分期将其分为A组(初发期白内障病例,53例)、B组(未成熟期白内障病例,41例)、C组(成熟期白内障病例,50例)和D组(过熟期白内障病例,10例),选取50例健康志愿者作为对照组,对各组研究对象的空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、胰岛素水平及血清visfatin、TNF-α水平进行检测和比较。结果随着白内障临床分期的升高,T2DM合并白内障患者的FBG、Hb A1c水平及血清visfatin、TNF-α水平逐渐升高,且均高于对照组,而胰岛素水平逐渐降低,且均低于对照组,组间差异均有统计学意义(P0.05);Spearman等级相关分析结果显示,T2DM合并白内障患者的白内障分期与FBG、Hb Alc、TNF-α、visfatin均呈正相关关系,而与胰岛素呈负相关关系(P0.05)。结论 T2DM患者的白内障分期与其血清visfatin、TNF-α水平具有相关性,这两种血清因子的过表达可能参与了糖尿病性白内障的进展过程,可作为评价患者病情的辅助指标。
[Abstract]:Objective to observe and analyze the relationship between serum visfatin (visfatin) and tumor necrosis factor- 伪 (TNF- 伪) and cataract in elderly patients with type 2 diabetes mellitus (T2DM). Methods 154 elderly patients with T2DM complicated with cataract were selected. According to the stage of cataract, it was divided into group A (53 cases of primary cataract) and group B (41 cases of immature cataract (50 cases of mature cataract) and group D (10 cases of overmature cataract). 50 healthy volunteers served as control group, Fasting blood glucose (FBGG), glycosylated hemoglobin (HbA1cU), insulin and serum visfatinine TNF- 伪 were measured and compared in each group. Results with the increase of clinical stage of cataract, the levels of FBGV HbA1c and serum levels in T2DM patients with cataract were determined and compared. The levels of visfatinine TNF- 伪 increased gradually, The results of Spearman grade correlation analysis showed that there was a positive correlation between cataract stage and FBGG HbAlcTNF- 伪 visfatin in T2DM patients with cataract. Conclusion the stage of cataract in patients with T2DM is correlated with the level of serum visfatinine TNF- 伪, and the overexpression of these two serum factors may be involved in the progression of diabetic cataract. It can be used as an auxiliary index to evaluate the patient's condition.
【作者单位】：深圳市眼科医院(暨南大学附属深圳眼科医院)深圳眼科学重点实验室;中山大学附属第二医院眼科;
【基金】：广东省中医药局非资助项目(20152056)
【分类号】：R587.2;R776.1

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