ATM基因单核苷酸多态性与鼻咽癌易感性及复发的相关性

发布时间：2018-03-03 08:19

本文选题：鼻咽癌　切入点：单核苷酸多态性　出处：《现代肿瘤医学》2016年08期 　论文类型：期刊论文

【摘要】：目的:探讨ATM基因单核苷酸多态性与鼻咽癌易感性与复发的关系。方法:采用病例对照研究,采集来自北方地区不同医院的鼻咽癌病人193例、正常人群231例静脉血,酚-氯仿法提取基因,Taqman realtime PCR方法及SDS软件对ATM基因型进行分型。SPSS 13.0软件包进行数据分析,以χ~2检验比较SNPs基因型在病例与对照之间分布的差异,以单因素和多因素logistic回归计算比值比(odds ratio,OR)及95%可信区间(confidence interval,CI)。结果:单因素分析显示,ATM126713位点的各基因型与鼻咽癌易感性不相关,P值0.075,OR值1.422,95%CI为0.963~2.199。但ATM126713位点的杂合基因型(G/A)经校正年龄、性别、吸烟状态后显示与鼻咽癌易感性相关,P值0.024,OR=1.636,95%CI为1.067~2.509。ATM126713位点各基因型与鼻咽癌复发不相关。结论:ATM126713位点G/A杂合型基因是鼻咽癌风险基因型,ATM126713位点各基因型与鼻咽癌复发无相关性。
[Abstract]:Objective: to investigate the relationship between single nucleotide polymorphism (SNP) of ATM gene and susceptibility and recurrence of nasopharyngeal carcinoma (NPC). Methods: a case-control study was conducted in 193 NPC patients from different hospitals in northern China and 231 normal controls. Taqman realtime PCR and SDS software were used to analyze the genotypes of ATM genotypes. SPSS13.0 software package was used to analyze the distribution of ATM genotypes. 蠂 ~ 2 test was used to compare the distribution of SNPs genotypes between cases and controls. Odds odds odds ratio (odds odds odds ratio) and 95% confidence intervalescence calculated by univariate logistic regression. Results: univariate analysis showed that each genotype of ATM126713 locus had no correlation with NPC susceptibility (P = 0.075) or OR = 1.42222 / 95CI = 0.9633.But heterozygosity gene of ATM126713 locus was 0.9632.199. Type G / A) adjusted age, Sex, Smoking status showed that there was no correlation between the genotype and recurrence of nasopharyngeal carcinoma (NPC). Conclusion there is no correlation between the genotype of G / A heterozygous gene at 1: 1 ATM126713 locus and the recurrence of nasopharyngeal carcinoma. Conclusion there is no correlation between the genotype at ATM126713 and the recurrence of nasopharyngeal carcinoma.
【作者单位】：中国医科大学附属第四医院放疗科;辽宁省肿瘤医院肿瘤放疗三科;辽宁边防总队医院;
【基金】：辽宁省省直医院改革重点临床科室诊疗能力建设项目(编号:LNCCC-B08-2014)
【分类号】：R739.63

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