不同途径吸入布地奈德气雾剂治疗儿童过敏性鼻炎哮喘综合征的临床效果对比

发布时间：2018-03-06 16:32

本文选题：过敏性鼻炎　切入点：支气管哮喘　出处：《中国医药导报》2016年03期 　论文类型：期刊论文

【摘要】：目的探讨不同途径吸入布地奈德气雾剂治疗儿童过敏性鼻炎哮喘综合征(CARAS)的临床效果。方法选择2011年6月~2015年1月在深圳市人民医院儿科治疗的轻、中度CARAS患儿113例为研究对象,根据随机数字表法将其分为三组:A组(39例)采用经口吸入布地奈德气雾剂,200μg/次,2次/d;B组(36例)采用闭嘴经鼻吸入布地奈德气雾剂,200μg/次,2次/d;C组(38例)采用经口吸入布地奈德气雾剂(100μg/次,2次/d)与经鼻吸入布地奈德鼻喷雾剂200μg/次(每边鼻腔各喷100μg/次,1次/d);均进行8周治疗。记录三组患儿治疗前后的相关参数并进行比较。结果与A组比较,B组临床症状评分、肺功能、EOS绝对值、血清总Ig E等水平有显著改善(均P0.05);B组总有效率明显高于A组(χ2=5.943,P0.05);而B组与C组比较,差异无统计学意义(均P0.05)。C组不良反应发生率明显高于A组和B组,B组与C组比较,差异有统计学意义(χ2=11.402,P0.05)。结论采用闭嘴经鼻吸入200μg/次、2次/d(400μg/d)布地奈德气雾剂治疗轻、中度CARAS患儿效果显著,不良反应少,操作更简便,值得临床推广和应用。
[Abstract]:Objective to investigate the clinical effect of inhaling budesonide aerosol in children with allergic rhinitis asthma syndrome (CARAS). 113 children with moderate CARAS were studied. According to the method of random number table, it was divided into three groups (39 cases in group 1: a) 36 cases in group B were treated with budesonide aerosol (200 渭 g / time) and 36 cases in group B (n = 36). Group C (n = 38) was treated with inhaled budesonide aerosol 200 渭 g / time via shut up and nasal entrapment of budesonide (n = 38, n = 38) by oral inhalation of budesonide aerosol (n = 38). Budesonide aerosol (100 渭 g / d) and inhaled budesonide nasal spray (200 渭 g / time) were administered for 8 weeks. The parameters of the three groups were recorded and compared before and after treatment. The clinical symptom score of group B was compared with that of group A. The absolute value of EOS and the level of serum IgE were significantly improved in group B than in group A (P 0.05), and the total effective rate in group B was significantly higher than that in group A (蠂 2 = 5.943), while in group B, it was significantly higher than that in group C (P < 0.05), but there was no significant difference between group B and group C (P > 0.05). The incidence of adverse reactions in group C was significantly higher than that in group A and group B, and the difference was statistically significant (蠂 2 + 11.402% P 0.05). Conclusion budesonide aerosol was used to treat mild patients with 200 渭 g / d oral inhalation of 200 渭 g / d of budesonide. The effect of moderate CARAS is remarkable, the adverse reaction is less, and the operation is more simple, so it is worth popularizing and applying in clinic.
【作者单位】：广东省深圳市人民医院儿科;广东省深圳市人民医院耳鼻喉科;
【分类号】：R765.21

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