玻璃体腔注射雷珠单抗治疗严重增生型糖尿病视网膜病变的临床观察

发布时间：2018-03-06 22:19

本文选题：雷珠单抗　切入点：严重增生型糖尿病视网膜病变　出处：《国际眼科杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的:分析并探讨玻璃体腔注射雷珠单抗治疗严重增生型糖尿病视网膜病变的临床效果。方法:选取2012-05/2015-05在我院接受治疗的严重增生型糖尿病视网膜疾病患者120例120眼,根据病情及患者意愿分为观察组与对照组,每组60例60眼。两组患者在术前均进行超声检查、超声生物显微镜检查、眼底照相、眼压检查等一系列眼部检查。两组患者均行玻璃体切割手术,在此基础上,观察组联合注射雷珠单抗,对照组仅行玻璃体切割手术。结果:观察组治疗有效率为80.0%,对照组治疗有效率为61.7%。观察组治疗有效率明显高于对照组,差异具有统计学意义(P0.05)。观察组术后眼压为14.96±3.53mmHg,LogMAR BCVA为0.82±0.21。对照组术后眼压为15.04±3.84mmHg,LogMAR BCVA为1.05±0.22。两组患者治疗后眼压无统计学意义(P0.05),LogMAR BCVA与治疗前相比有明显差异,观察组更加明显,具有统计学意义(P0.05)。两组患者治疗后炎症因子浓度存在显著差异,具有统计学意义(P0.05)。结论:玻璃体腔注射雷珠单抗治疗严重增生型糖尿病视网膜病变的临床效果显著值得推广。
[Abstract]:Objective: to analyze and evaluate the clinical effect of vitreous injection of Lei Zhu McAb in the treatment of severe proliferative diabetic retinopathy. Methods: 120 cases (120 eyes) of severe proliferative diabetic retinopathy treated in our hospital in 2012-05 / 2015-05 were selected. According to the condition and the wishes of the patients, they were divided into the observation group and the control group with 60 cases and 60 eyes in each group. The patients in both groups underwent ultrasonic examination, ultrasound biomicroscopy, fundus photography before operation. Intraocular pressure examination and a series of eye examinations. Both groups of patients underwent vitrectomy. On this basis, the observation group was given a combined injection of Lei Zhu McAb. Results: the effective rate of treatment was 80.0 in the observation group and 61.7 in the control group. The effective rate of treatment in the observation group was significantly higher than that in the control group. The intraocular pressure (IOP) of the observation group was 14.96 卤3.53mm HggMar BCVA (0.82 卤0.21), while that of the control group was 15.04 卤3.84mm HggMar BCVA (1.05 卤0.22.There was no significant difference between the two groups in intraocular pressure (P0.05LogMAR BCVA), especially in the observation group. There was significant difference in the concentration of inflammatory factors between the two groups after treatment. Conclusion: the clinical effect of vitreous injection of Lei Zhu McAb in the treatment of severe proliferative diabetic retinopathy is obviously worth popularizing.
【作者单位】：喀什地区第一人民医院眼科;
【分类号】：R587.2;R774.1

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