克拉霉素强化治疗用于慢性鼻窦炎患者的临床观察

发布时间：2018-03-13 10:37

  本文选题：慢性鼻窦炎　切入点：克拉霉素　出处：《中国药房》2017年30期 　论文类型：期刊论文

【摘要】：目的:探讨克拉霉素强化治疗用于慢性鼻窦炎患者的疗效、安全性及对血清炎性细胞因子的影响。方法:186例慢性鼻窦炎患者随机分为对照1组(62例)、对照2组(62例)和观察组(62例)。对照1组患者口服阿莫西林克拉维酸钾片(7∶1)0.457 g,每日3次;对照2组患者口服克拉霉素分散片0.25 g,每日1次;观察组患者口服克拉霉素分散片第1周0.5 g,每日2次,第2周0.25g,每日2次。各组患者疗程均为2周。观察各组患者的临床疗效和治疗前后各临床症状评分、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、超敏C反应蛋白(hs-CRP)水平及不良反应发生情况。结果:总有效率观察组(93.55%)对照2组(80.65%)对照1组(65.51%),差异均有统计学意义(P0.05)。治疗前,各组患者各临床症状评分、TNF-α、IL-6、hs-CRP水平比较,差异均无统计学意义(P0.05);治疗后,各组患者各临床症状评分、TNF-α、IL-6、hs-CRP水平均显著低于同组治疗前,且观察组对照2组对照1组,差异均有统计学意义(P0.05)。观察组、对照2组患者不良反应发生率均显著低于对照1组,差异均有统计学意义(P0.05),但观察组与对照2组间比较,差异无统计学意义(P0.05)。结论:克拉霉素强化治疗用于慢性鼻窦炎的疗效显著,可改善患者的临床症状,降低血清炎性细胞因子水平,且未增加不良反应的发生。
[Abstract]:Objective: to investigate the curative effect of clarithromycin intensive therapy in patients with chronic sinusitis. Methods 186 patients with chronic sinusitis were randomly divided into control group (n = 62) and control group (n = 62) and observation group (n = 62) and control group (n = 62). 7: 1: 0.457 g, 3 times a day; Patients in the control group were given clarithromycin dispersible tablets 0.25 g once a day, while those in the observation group received 0.5 g clarithromycin dispersible tablets once a day twice a day. The second week was 0.25 g, twice a day. The course of treatment was 2 weeks. The clinical efficacy and clinical symptom scores before and after treatment were observed. The levels of TNF- 伪, IL-6, hs-CRP and the occurrence of adverse reactions. Results: the total effective rate in observation group was 93.55) and the control group was 80.65) the difference was statistically significant before treatment. After treatment, the levels of TNF- 伪 and IL-6 hs-CRP in each group were significantly lower than those before treatment, and the levels of TNF- 伪 and IL-6 hs-CRP in the observation group were significantly lower than those in the control group, and there was no significant difference in the levels of TNF- 伪 and IL-6hs-CRP between the two groups after treatment, and there was no significant difference in the levels of TNF- 伪 and IL-6hs-CRP between the two groups after treatment. The incidence of adverse reactions in the observation group and the control group was significantly lower than that in the control group (P 0.05), but there was a significant difference between the observation group and the control group. Conclusion: clarithromycin intensive therapy for chronic sinusitis can improve the clinical symptoms, reduce the level of serum inflammatory cytokines, and does not increase the occurrence of adverse reactions.
【作者单位】： 南阳市中心医院静脉用药调配中心;南阳市中心医院耳鼻喉科;
【分类号】：R765.41
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本文编号：1606018