视网膜母细胞瘤患者全身化学药物治疗联合局部治疗的临床效果

发布时间：2018-03-17 03:04

  本文选题：视网膜母细胞瘤　切入点：化疗　出处：《实用癌症杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的观察视网膜母细胞瘤(retinoblastoma,RB)患者全身化学药物治疗联合局部治疗的临床效果。方法临床纳入RB患者19例,共有28只眼接受了全身化学药物治疗联合局部治疗。全身化疗一般进行6个疗程,每个疗程3~4周,主要化疗药物包括长春新碱、环磷酰胺、依托泊甙以及卡铂等。此外,根据患者的情况给予局部治疗。局部治疗方法包括激光光凝、冷冻、经瞳孔温热疗法、钌106放射敖贴器局部放疗以及眼球摘除等。对患者进行3~61个月的随访,平均随访时间为31个月。观察患者的临床生存率、眼球保留率以及临床疗效。结果随访1年内,有16例患者存活,存活率为84.21%,转移率为5.26%;2年内生存率为78.95%,转移率为10.53%。对16例存活患者23只患眼进行分析,发现肿瘤分期为Ⅰ~Ⅱ期、Ⅲ~Ⅳ、Ⅴ期者眼球保留率分别为100.00%、40.00%、16.67%。3例死亡病例均为肿瘤分期Ⅳ期及以上的患者。结论 RB患者进行全身化学药物联合局部治疗,具有较好的临床疗效,早期治疗患者患眼的保留率较高。
[Abstract]:Objective to observe the clinical effect of systemic chemotherapeutic therapy combined with local therapy in patients with retinoblastoma (RBB). Methods 19 patients with RB were included in this study. A total of 28 eyes received systemic chemotherapeutic therapy combined with local treatment. General systemic chemotherapy was performed for 6 courses of treatment for 3 to 4 weeks each. The main chemotherapeutic drugs included vincristine, cyclophosphamide, etoposide, carboplatin, and so on. Local treatment was given according to the patient's condition. The local treatment methods included laser photocoagulation, freezing, transpupillary thermotherapy, local radiotherapy with ruthenium 106 radiator and enucleation, etc. The patients were followed up for 3 to 61 months. The average follow-up time was 31 months. The clinical survival rate, eyeball retention rate and clinical efficacy were observed. The survival rate was 84.21 and the metastasis rate was 5.26. The 2-year survival rate was 78.95, and the metastasis rate was 10.53.Twenty three eyes of 16 surviving patients were analyzed, and it was found that the tumor stage was 鈪，

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