中药注射剂联合放疗治疗鼻咽癌疗效及安全性的网状Meta分析

发布时间：2018-03-18 18:18

  本文选题：中药注射剂　切入点：鼻咽癌　出处：《实用预防医学》2016年06期 　论文类型：期刊论文

【摘要】：目的采用网状meta分析,以单纯放疗为对照干预措施比较中药注射剂联合放疗治疗鼻咽癌的疗效及安全性。方法检索Cochrane Library、Pub Med、EMbase、CBM、CNKI、维普数据库,收集所有中药注射液联合放疗治疗鼻咽癌的随机对照试验(RCTs)和半随机对照试验(CCT),按预先制定的纳入与排除标准筛选和纳入,并对纳入文献质量进行评价,数据采用Microsoft Excel软件加载Net Meta XL宏命令调用Win BUGS1.4.3软件进行分析。结果共纳入9种中药注射剂,23个研究,网状Meta分析结果显示,与单纯放疗相比,完全有效率方面OR康莱特注射剂=3.42,95%CI(1.60,7.11);OR康艾注射剂=9.18,95%CI(1.40,100.50),优于对照组,其余差异无统计学意义。Ⅱ~Ⅳ级口腔黏膜炎方面,OR参芪扶正注射剂=0.12,95%CI(0.02,0.63);OR华蟾素注射剂=0.20,95%CI(0.04,0.93);OR康艾注射剂=0.25,95%CI(0.06,0.98);OR艾迪注射剂=0.31,95%CI(0.14,0.72);OR康莱特注射剂=0.35,95%CI(0.12,0.97);OR复方苦参注射剂=0.50,95%CI(0.26,0.93),优于对照组,其余差异无统计学意义。结论在完全有效率方面,康莱特注射剂效果最好的可能性最大,在Ⅱ~Ⅳ口腔黏膜炎发生率方面,参芪扶正注射剂效果最好的可能性最大,该结论有待更多高质量、大样本、长期随访的RCTs进一步验证。
[Abstract]:Objective to compare the efficacy and safety of traditional Chinese medicine injection combined with radiotherapy in the treatment of nasopharyngeal carcinoma by reticular meta analysis. Methods the database of Cochrane Library Pub Medbase was searched. RCTs and CCTX were collected from all Chinese traditional medicine injection combined with radiotherapy for nasopharyngeal carcinoma (RCTs) and semi-randomized controlled trial (CRT). The inclusion was screened and included according to the pre-established criteria of inclusion and exclusion, and the quality of the literature was evaluated. The data were analyzed by loading Net Meta XL macro command with Microsoft Excel software and calling Win BUGS1.4.3 software. The results included 9 kinds of traditional Chinese medicine injections, 23 studies, and the results of network Meta analysis showed that compared with radiotherapy alone, the data were compared with radiotherapy alone. In terms of total effective rate, OR Kanglaite injection was 3.42 ~ 95 CIQ 1.60 ~ 7.11 and OR Kangai injection was 1.40 ~ 100.50%, which was better than that in control group. There was no statistical difference between the other two groups. In grade 鈪，

本文编号：1630747