高度近视合并青光眼患者黄斑区脉络膜厚度的多元回归分析（英文）

发布时间：2018-03-19 09:37

本文选题：高度近视　切入点：原发性开角型青光眼　出处：《国际眼科杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的:探讨高度近视合并原发性开角型青光眼(POAG)患者的黄斑区脉络膜厚度分布特征及影响黄斑区脉络膜厚度的相关因素。方法:研究共纳入高度近视合并POAG患者18例32眼,POAG患者20例36眼,以及高度近视患者21例33眼。采用频域OCT增强深度扫描测定中心凹下(SFCT)、距中心凹1mm和3mm处上、下、鼻、颞四个方位的脉络膜厚度(S1CT、S3CT、I1CT、I3CT、N1CT、N3CT、T1CT、T3CT)。比较三组间黄斑区脉络膜厚度的差异,并利用多元回归分析对POAG患者的诊断、屈光度、年龄、眼压、角膜厚度、视野缺损等对黄斑区脉络膜厚度的影响进行分析。结果:高度近视合并POAG患者的黄斑区脉络膜厚度较POAG患者在各测量位置均明显变薄(均P0.05),但与高度近视患者在各测量点的脉络膜厚度差异均无统计学意义(均P0.05)。屈光度是POAG患者黄斑区各测量点脉络膜厚度的主要影响因素,颞侧距中心凹3mm处的脉络膜厚度(S3CT)受年龄的影响,而诊断、视野缺损、眼压及角膜厚度不是脉络膜厚度的影响因素。结论:高度近视合并POAG患者黄斑区脉络膜厚度比单纯POAG患者薄,但与高度近视患者无统计学差异,黄斑区脉络膜厚度与青光眼性视神经损伤程度无明显关联。
[Abstract]:Objective: to investigate the distribution characteristics of choroidal thickness in macular area and the related factors affecting choroidal thickness in high myopia patients with primary open-angle glaucoma (Poag). Methods: to study the characteristics of choroidal thickness in high myopia patients with POAG. 18 cases (32 eyes) with Poag, 20 cases (36 eyes), And 33 eyes of 21 patients with high myopia. The choroidal thickness of the inferior fovea was measured by frequency-domain OCT enhanced depth scanning at the distance of 1 mm and 3 mm from the central fovea. The choroidal thickness of S1CTT S3CTV I _ 1CTN _ 1CTN _ 3CTN _ 3CTN _ 3CTN _ 3CTN _ 3CTT _ 3CTT _ 3CTT _ 3CTT _ 3CTT _ 3 in the macular area was compared among the three groups. The diagnosis, diopter, age, intraocular pressure, corneal thickness of POAG patients were analyzed by multivariate regression analysis. Results: the choroidal thickness of macular area in patients with high myopia complicated with POAG was significantly thinner than that in patients with POAG (all P0.05%, P 0.05), but the thickness of choroidal thickness in high myopia patients with POAG was significantly thinner than that in patients with high myopia (P0.05%). There was no significant difference in choroidal thickness between the measured points (all P0.050.The diopter was the main influencing factor of choroidal thickness in the macular area of POAG patients. The thickness of choroid at 3 mm from the fovea temporalis was affected by age. Conclusion: the choroidal thickness in high myopia with POAG is thinner than that in POAG alone, but there is no significant difference between high myopia and high myopia. There was no significant correlation between the choroidal thickness of macular area and the degree of glaucoma optic nerve injury.
【作者单位】：华中科技大学同济医学院附属同济医院眼科;美国德克萨斯州休斯顿贝勒医学院眼科;
【分类号】：R778.11;R775

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