丹参酮联合角膜缘干细胞移植术治疗翼状胬肉的临床观察

发布时间：2018-03-20 08:43

本文选题：丹参酮　切入点：翼状胬肉　出处：《中国药房》2017年14期 　论文类型：期刊论文

【摘要】：目的:观察丹参酮联合角膜缘干细胞移植术治疗翼状胬肉的临床疗效和安全性。方法:采用回顾性分析方法,选取我院2010年2月-2014年9月收治的原发性翼状胬肉患者97例(118眼),根据用药情况分为观察组48例(57眼)和对照组49例(61眼)。两组患者均行自体角膜缘干细胞移植术。对照组患者于术前1周开始给予妥布霉素地塞米松滴眼液1~2滴,每4~6 h 1次,行常规治疗;观察组患者在对照组基础上给予丹参酮胶囊0.5 g,po,tid,连用3个月。比较两组患者角膜上皮修复时间和局部症状消退时间,观察两组患者术前及术后1、3个月角膜散光度和矫正视力情况,并统计两组患者复发和不良反应发生情况。结果:观察组患者角膜上皮修复时间、局部症状消退时间均显著短于对照组,差异有统计学意义(P0.05)。两组患者术前及术后1个月角膜散光、矫正视力比较,差异无统计学意义(P0.05);与术前比较,术后1、3个月两组患者角膜散光度显著降低、矫正视力显著升高,且术后3个月观察组显著优于对照组,差异均有统计学意义(P0.05)。观察组患者复发率为3.51%,显著低于对照组的14.75%,差异有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:丹参酮联合自体角膜缘干细胞移植术治疗翼状胬肉,能显著缩短角膜上皮修复和局部症状消退时间,恢复患者视功能,降低复发率,且安全性好。
[Abstract]:Objective: to observe the clinical efficacy and safety of tanshinone combined with limbal stem cell transplantation in the treatment of pterygium. 97 cases of primary pterygium treated in our hospital from February 2010 to September 2014 were divided into observation group (48 cases, 57 eyes) and control group (49 cases, 61 eyes). The patients in the control group were given tobramycin dexamethasone eye drops 1 to 2 drops one week before operation. The patients in the observation group were treated with tanshinone capsule 0.5 g potid for 3 months on the basis of the control group. The corneal epithelium repair time and the time of local symptom regression were compared between the two groups. The corneal astigmatism and corrected visual acuity were observed before and 1, 3 months after operation. The regression time of local symptoms was significantly shorter than that of the control group (P 0.05). There was no significant difference in corrected visual acuity between the two groups in corneal astigmatism before and 1 month after operation (P 0.05), and there was no significant difference between the two groups before and after operation. At 1 and 3 months after operation, the corneal astigmatism and corrected visual acuity of the two groups were significantly decreased, and the observation group was significantly better than the control group 3 months after operation. The recurrence rate of the patients in the observation group was 3.51, which was significantly lower than that in the control group (14.75%), and the difference was statistically significant (P 0.05). The incidence of adverse reactions in the two groups was higher than that in the control group. Conclusion: the treatment of pterygium with tanshinone combined with autogenous limbal stem cell transplantation can significantly shorten the time of corneal epithelial repair and local symptom regression, restore the visual function of the patients, and reduce the recurrence rate, and the safety is good.
【作者单位】：安徽人口职业学院附属医院眼耳鼻喉科;
【基金】：安徽省高等学校省级质量工程项目(No.2014jyxm683) 安徽省教育厅高校自然科学研究重点项目(No.KJ2016A249)
【分类号】：R779.6

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