喉部或下咽部恶性肿瘤患者发生阻塞性睡眠呼吸暂停综合征的影响因素研究

发布时间：2018-03-21 19:41

  本文选题：喉肿瘤　切入点：咽肿瘤　出处：《中国全科医学》2017年24期 　论文类型：期刊论文

【摘要】：目的探讨喉部或下咽部恶性肿瘤患者发生阻塞性睡眠呼吸暂停综合征(OSAS)的影响因素,为防止肿瘤进一步生长、降低手术风险及术后并发症、提高患者的生活质量提供帮助。方法选取2016年2—9月于郑州大学第一附属医院耳鼻咽喉头颈外科就诊的符合纳入标准的喉部或下咽部恶性肿瘤患者50例,并收集患者的临床资料。采用便携式睡眠监测仪监测患者睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度等数据;其中AHI≥5次/h即可诊断为OSAS。根据患者是否发生OSAS,将其分为OSAS组和非OSAS组,比较两组性别、年龄、体质指数(BMI)、肿瘤部位、肿瘤分期。并采用多因素Logistic回归分析分析喉部或下咽部恶性肿瘤患者发生OSAS的影响因素。结果50例患者中男性较多,占94%;平均年龄(63.9±9.9)岁;平均BMI(22.5±3.0)kg/m~2;肿瘤部位:声门上型13例(26%),声门型25例(50%),下咽12例(24%);肿瘤分期:T_1期20例(40%),T_2期15例(30%),T_3期6例(12%),T_4期9例(18%);平均AHI(15.8±11.9)次/h;平均最低血氧饱和度72.8%±10.8%。50例患者中AHI≥5次/h 43例,即OSAS组43例,非OSAS组7例。OSAS组患者年龄大于非OSAS组患者(P0.05)。多因素Logistic回归分析结果显示,年龄是喉部或下咽部恶性肿瘤患者发生OSAS的危险因素[OR=1.133,95%CI(1.023,1.255),P=0.016]。结论喉部或下咽部恶性肿瘤患者OSAS发生率较高,且年龄是其发生OSAS的危险因素,而BMI、肿瘤部位、肿瘤分期与OSAS的发生无明显关系。
[Abstract]:Objective to investigate the influencing factors of obstructive sleep apnea syndrome (OSAS) in patients with malignant tumor of larynx or hypopharynx, in order to prevent tumor from growing further and reduce the risk of operation and postoperative complications. Methods from February to September 2016, 50 patients with malignant tumor of larynx or hypopharynx were enrolled in the department of otolaryngology and head and neck surgery of the first affiliated Hospital of Zhengzhou University. The clinical data of patients were collected, and the data of AHIH and minimum oxygen saturation were monitored by portable sleep monitor in patients with sleep apnea hypopnea. AHI 鈮，

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