老年性聋患者听觉事件相关电位特征分析

发布时间：2018-03-22 04:04

本文选题：老年性聋　切入点：听觉事件相关电位　出处：《听力学及言语疾病杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的初步研究老年性聋患者的听觉事件相关电位(auditory event-related potential,AERP)失匹配负波(mismatch negativity,MMN)和P300的变化特征。方法采用oddball刺激序列,对20例健康青年志愿者(对照组)、20例老年听力正常者(老年听力正常组)和20例老年性聋患者(老年性聋组)进行AERP测试,在阅读状态下获得MMN波形,在集中注意力计数状态下获得P300波形,比较三组MMN、P300波形的潜伏期和波幅。结果老年性聋组MMN潜伏期为187.38±29.63 ms,与老年听力正常组(160.10±23.21 ms)和对照组(148.22±19.30 ms)相比明显延长(P0.01),老年听力正常组潜伏期与对照组比较差异有统计学意义(P0.05),三组MMN波幅差异无统计学意义(P0.05);老年性聋组P300潜伏期为369.83±27.09,较老年听力正常组(332.89±25.60 ms)和对照组(318.51±22.32 ms)明显延长(P0.01),三组P300波幅差异无统计学意义(P0.05)。结论老年性聋患者听觉中枢功能受损,认知功能减退,MMN、P300可作为评估老年性聋患者听觉中枢功能、认知功能的客观检查方法。
[Abstract]:Objective to study the characteristics of auditory event-related potential (AERP) mismatch negative mismatch (MMNs) and P300 in patients with presbycusis. Methods oddball stimulation sequence was used. AERP was performed in 20 healthy young volunteers (control group, 20 normal aged hearing subjects) and 20 patients with presbycusis (presbycusis group). The MMN waveforms were obtained in reading state. Get the P300 waveform in the focus count state, Results the latency of MMN in the aged hearing loss group was 187.38 卤29.63 Ms, which was significantly longer than that in the aged normal group (160.10 卤23.21 Ms) and the control group (148.22 卤19.30 Ms). The latency of P300 was 369.83 卤27.09 in the presbycusis group, 332.89 卤25.60 Ms in the aged hearing control group and 318.51 卤22.32 Ms in the control group. There was no significant difference in the P300 amplitude between the three groups. Conclusion there is no significant difference in the P300 amplitude among the three groups. The hearing center function of the patients with annual deafness was impaired. MMNN P300 can be used as an objective method to evaluate auditory central function and cognitive function in patients with presbycusis.
【作者单位】：广西壮族自治区人民医院耳鼻咽喉科;
【基金】：广西壮族自治区卫生厅自筹经费科研课题(Z2014619)
【分类号】：R764.436

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