鼻渊合剂对FESS术后鼻窦黏膜内EGF和EGFR表达的影响

发布时间：2018-03-23 01:24

本文选题：慢性鼻-鼻窦炎　切入点：鼻内窥镜鼻窦手术　出处：《时珍国医国药》2014年12期 　论文类型：期刊论文

【摘要】：目的观察鼻渊合剂对慢性鼻-鼻窦炎患者FESS术后鼻窦黏膜内EGF及EGFR表达的影响。方法将符合标准的20例病例随机分为2组,其中治疗组10例(布地奈德鼻喷雾剂+鼻渊合剂),对照组10例(布地奈德鼻喷雾剂+克拉霉素分散片+吉诺通),两组均予相同的手术处理并分别在术后第1、2、4周采集标本,术后1周开始服药,采用HE染色、免疫组化检测EGF及EGFR表达情况。结果治疗组用药前后比较,用药1周后EGF表达强度增加(P0.05),EGFR表达强度明显增加(P0.01),用药3周后EGF、EGFR表达强度强度均明显增加(P0.01);对照组用药前后比较,用药1周后EGF表达强度显著增加(P0.01),EGFR表达强度有增加(P0.05),用药3周后EGF、EGFR表达强度均明显增加(P0.01);治疗组和对照组EGF、EGFR表达强度经组间比较无明显差异(P0.05)。结论术后运用鼻渊合剂在促进黏膜修复,加速创面愈合方面有一定作用,其机制可能与增加EGF、EGFR表达有关。
[Abstract]:Objective to observe the effect of Biyuan mixture on the expression of EGF and EGFR in nasal mucosa of patients with chronic rhinosinusitis after FESS. Methods Twenty patients with chronic rhinosinusitis were randomly divided into two groups. The treatment group (budesonide nasal spray) and the control group (budesonide nasal spray) and control group (budesonide nasal spray clarithromycin dispersible tablets) were treated with the same surgical treatment and the specimens were collected 4 weeks after operation. He staining and immunohistochemical staining were used to detect the expression of EGF and EGFR. Results in the treatment group, the expression of EGF and EGFR were compared before and after treatment. After one week, the expression intensity of EGF was significantly increased in P0.05, P0.01A, 3 weeks later, the expression intensity of EGF was significantly increased in the control group, the control group was compared before and after treatment, and the expression intensity of P0.01 was significantly increased in the control group before and after treatment, and the expression intensity of EGF in the control group was significantly increased after 3 weeks. After one week of administration, the expression of EGF increased significantly (P 0.01), and the expression intensity of EGFR increased significantly 3 weeks after treatment. There was no significant difference between the treatment group and the control group in the expression intensity of EGFR. Conclusion: after operation, the expression intensity of EGFR is not significantly different from that of the control group. Conclusion it is concluded that there is no significant difference in the expression intensity of EGFR between the treatment group and the control group. Conclusion: after operation, there is no significant difference in the expression of EGF between the treatment group and control group. The mixture is promoting mucosal repair, The mechanism of accelerating wound healing may be related to the increase of EGFR expression.
【作者单位】：南京中医药大学;南京中医药大学附属医院;江苏省无锡市中医院;
【基金】：江苏省中医药局中医药科研项目(No.HZ07063)
【分类号】：R276.1

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