桉柠蒎肠溶软胶囊预防儿童急性中耳炎鼓室积液的效果研究

发布时间：2018-03-24 07:13

本文选题：黏液调节剂　切入点：儿童　出处：《听力学及言语疾病杂志》2017年06期

【摘要】：目的观察桉柠蒎肠溶软胶囊预防儿童急性中耳炎鼓室积液的效果。方法 2013年4月至2016年9月发病48小时内就诊的341例(497耳)6~12岁儿童急性中耳炎(非化脓性)患儿随机分为实验组(172例46耳)和对照组(169例251耳),对照组给予1%苯酚甘油滴耳,糠酸莫米松喷鼻剂喷鼻,每日一次,实验组在同对照组治疗基础上口服桉柠蒎肠溶软胶囊半个月;于发病第7日和第14日复诊,比较两组症状和体征变化,对照组7日复诊时明确鼓室积液的患儿加用桉柠蒎肠溶软胶囊。结果7日复诊时对照组发生鼓室积液110例(170耳)(65.09%,110/169),实验组发生鼓室积液51例(70耳)(29.65%,51/172),前者高于后者(P0.01);14日复诊时,对照组仍有鼓室积液41例(66耳)(24.26%,41/169),实验组鼓室积液32例(36耳)(18.60%,32/172),前者高于后者(P0.05)。14日复诊时对照组7日复诊确诊为鼓室积液的110患儿中规律服药的75例患儿中鼓室积液消失54例(60耳)(72.0%,54/75),未规律服药的35例患儿中鼓室积液消失15例(22耳)(42.86%,15/35),差异有统计学意义(P0.01)。结论儿童急性中耳炎患者发病后口服桉柠蒎肠溶软胶囊能够有效降低鼓室积液的发生率,发生鼓室积液后加用该药可促进积液的排出。
[Abstract]:Objective to observe the effect of eucalyptus lime-pine-dissolving soft capsule on the prevention of tympanic effusion in children with acute otitis media. Methods 341 cases of acute otitis media (non-suppurative) in children aged 6 to 12 years old from April 2013 to September 2016 within 48 hours of onset were studied. Children were randomly divided into experimental group (n = 172, n = 46) and control group (n = 169, n = 251). Momethasone furoate nasal spray, once a day, the experimental group took eucalyptus pinpinenteric-soluble soft capsule for half a month on the basis of the same treatment as the control group, and the symptoms and signs of the two groups were compared on the 7th and 14th day after the onset of the disease. The children in the control group were treated with eucalyptus pinpinol enteric-soluble soft capsule on the 7th day. Results on the 7th day, 110 cases of tympanic effusion occurred in the control group (65.09%), and 51 cases in the experimental group had hydrotympanic effusion (29.65%), which was higher than that in the latter group (P 0.01); on the 14th day, the patients in the control group had 65.09% of tympanic effusion, and 51 cases in the experimental group had hydrotympanic effusion (29.65%), which was higher than that in the latter group (P 0.01). 41 cases of tympanic effusion were still found in the control group (41 cases, 66 ears) and 24.26% (41 / 169), while in the experimental group, 32 cases (36 ears) of tympanic effusion were 18.60% 32 / 172, the former was higher than that of the latter (P0.05%). On the 14th day, 75 cases of 110 children who were diagnosed with tympanic effusion on the 7th day in the control group were given regular medication of tympanic effusion. There were 54 cases of disappearance of 60 ears or 72.0% of 75% of the total, and of 35 cases of irregular drug taking, the tympanic effusion disappeared in 15 cases. The difference was statistically significant (P 0.01). Conclusion after the onset of acute otitis media in children, the incidence of tympanic effusion can be effectively reduced by taking eucalyptus lime enteric soft capsule after the onset of acute otitis media. After tympanic effusion occurs, adding this medicine can promote the efflux of effusion.
【作者单位】：大连市中心医院耳鼻咽喉头颈外科;
【分类号】：R764.21

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