治疗前血清球蛋白升高可预测鼻咽癌的不良预后

发布时间：2018-03-24 21:08

  本文选题：鼻咽癌　切入点：球蛋白　出处：《南方医科大学学报》2016年02期

【摘要】：目的探讨治疗前血清球蛋白水平对评估鼻咽癌预后的价值。方法回顾性收集2009年1月至2013年12月在南方医院初治的127例无远处转移鼻咽癌患者资料,包括治疗前血清球蛋白水平。采用ROC曲线选取血清球蛋白分界值从而将病例分成低球蛋白组和高球蛋白组,采用Kaplan-Meier和COX多因素分析的方法分析治疗前血清球蛋白水平对判断鼻咽癌预后的价值。结果 ROC曲线得出治疗前血清球蛋白的分界值为30.05 g/L。球蛋白水平与性别及N分期显著相关。Kaplan-Meier分析显示治疗前高球蛋白水平(30.05 g/L)预示不良的无进展生存率(P=0.019),总生存率(P=0.034),及无远处转移生存率(P=0.049)。多因素分析显示治疗前血清球蛋白水平是鼻咽癌进展的独立预后因素(HR=2.344,P=0.031)。结论治疗前血清球蛋白水平对鼻咽癌的预后评估有临床价值。
[Abstract]:Objective to evaluate the value of serum globulin level in evaluating the prognosis of nasopharyngeal carcinoma (NPC) before treatment. Methods the data of 127 patients with nasopharyngeal carcinoma without distant metastasis were collected retrospectively from January 2009 to December 2013. The ROC curve was used to select the serum globulin boundary value to divide the patients into low globulin group and high globulin group. Kaplan-Meier and COX multivariate analysis were used to analyze the value of serum globulin level in predicting prognosis of nasopharyngeal carcinoma before treatment. Results ROC curve showed that the boundary value of serum globulin before treatment was 30.05g / L 路globulin level, sex and N. Kaplan-Meier analysis showed that high globulin level (30.05 g / L) predicted poor progressive survival rate (P < 0.019), overall survival rate (P < 0.034), and metastasis free survival rate (P < 0.049). Multivariate analysis showed that the serum globulin level before treatment was nasopharyngeal carcinoma (NPC). Conclusion the serum globulin level before treatment is of clinical value in evaluating the prognosis of nasopharyngeal carcinoma.
【作者单位】： 南方医科大学南方医院放疗科;
【基金】：Supported by National Natural Science Foundation of China(81172586)~~
【分类号】：R739.63
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本文编号：1660035