幽门螺杆菌感染与青光眼的相关性研究

发布时间：2018-03-28 22:02

本文选题：幽门螺杆菌　切入点：青光眼　出处：《中华医院感染学杂志》2017年23期

【摘要】：目的探讨幽门螺杆菌感染与青光眼的相关性。方法选择2014年1月-2015年12月医院眼科原发性开角型青光眼患者60例为开角型青光眼组、原发性闭角型青光眼患者60例为闭角型青光眼组、性别及年龄相匹配的健康体检者60名为对照组;采用~(14)C-尿素呼气试验测量幽门螺杆菌浓度,采用胶体金标记免疫斑点渗滤法测定血清幽门螺杆菌免疫球蛋白G(IgG),采用光学相关断层成像测定视网膜神经纤维层厚度。结果开角型青光眼组幽门螺杆菌阳性率88.33%高于闭角型青光眼组35.00%和对照组31.67%(P0.05);开角型青光眼组血清幽门螺杆菌IgG阳性率85.00%高于闭角型青光眼组33.33%和对照组28.33%(P0.05);开角型青光眼组和闭角型青光眼组大视盘、中视盘、小视盘视网膜神经纤维层厚度均低于对照组(P0.05),开角型青光眼组大视盘、中视盘、小视盘视网膜神经纤维层厚度低于闭角型青光眼组(P0.05);开角型青光眼患者幽门螺杆菌浓度与青光眼患者视盘视网膜神经纤维层厚度呈负相关(P0.05)。结论原发性开角型青光眼患者幽门螺杆菌感染率高,幽门螺杆菌可能和原发性开角型青光眼的发病有关。
[Abstract]:Objective to investigate the correlation between Helicobacter pylori infection and glaucoma. Methods 60 patients with primary open-angle glaucoma in ophthalmology from January 2014 to December 2015 were selected as open-angle glaucoma group. 60 patients with primary angle-closure glaucoma were included in the angle-closure glaucoma group, and 60 healthy controls matched with sex and age were used to measure the concentration of Helicobacter pylori by C- urea breath test. Serum Helicobacter pylori immunoglobulin IgGG was determined by colloidal gold-labeled immunspot percolation and retinal nerve fiber layer thickness was measured by optical correlation tomography. Results the positive rate of Helicobacter pylori in open-angle glaucoma group was 88.33%. The positive rate of serum Helicobacter pylori IgG in open-angle glaucoma group was 85.00% higher than that in angle closure glaucoma group (33.33%) and control group (28.33%) (P 0.05). The thickness of retinal nerve fiber layer in middle and small optic disc was lower than that in control group (P 0.05). The thickness of retinal nerve fiber layer of small optic disc is lower than that of angle closure glaucoma group (P 0.05), the concentration of Helicobacter pylori in open-angle glaucoma patients is negatively correlated with the thickness of optic disc retinal nerve fiber layer of glaucoma patients (P 0.05). Conclusion Primary open-angle glaucoma patients have a negative correlation with the thickness of retinal nerve fiber layer of optic disc. The infection rate of Helicobacter pylori was high in patients with light eyes. Helicobacter pylori may be associated with primary open angle glaucoma.
【作者单位】：宁波市鄞州区第二医院眼科;
【基金】：浙江省医药卫生一般研究基金资助项目(2016KYA160)
【分类号】：R775

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