多西紫杉醇联合调强放射治疗局部晚期鼻咽癌临床观察

发布时间：2018-03-29 23:33

本文选题：多西紫杉醇　切入点：奈达铂　出处：《中华全科医学》2016年02期

【摘要】：目的探讨多西紫杉醇联合同步调强适形放疗对局部晚期鼻咽癌患者的临床疗效,为临床治疗提供参考。方法选择2011年6月—2014年6月42例局部晚期鼻咽癌患者,按照随机数字表法分为观察组与对照组,各21例。对照组男性14例,女性7例;平均年龄(52.77±6.11)岁;观察组男性15例,女性6例;平均年龄(53.15±5.47)岁。对照组使用5-氟尿嘧啶联合奈达铂同步调强适形放疗治疗,观察组使用奈达铂联合多西紫杉醇同步调强适形放疗治疗,对比2组治疗后近期缓解率、毒副反应、鼻咽大体肿瘤靶区体积缩小率。结果观察组完全缓解率为71.43%,近期有效率为90.48%,与对照组66.67%、85.71%比较差异无统计学意义(χ2完全缓解率=0.891,P=0.251;χ2近期有效率=0.922,P=0.185);观察组化疗前后鼻咽大体肿瘤靶区体积分别为(49.21±6.15)cm3、(36.14±5.07)cm3,体积缩小率为26.56%,均与对照组比较差异无统计学意义(P0.05);观察组恶心或呕吐、中性粒细胞减少、食欲减退、腹胀Ⅲ~Ⅳ度发生率均明显低于对照组,差异有统计学意义(P0.05)。结论多西紫杉醇联合同步调强适形放疗治疗局部晚期鼻咽癌效果显著,毒副作用可接受,值得临床推广应用。
[Abstract]:Objective to investigate the clinical efficacy of docetaxel combined with synchronous intensity modulated conformal radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma (NPC). Methods 42 patients with locally advanced nasopharyngeal carcinoma from June 2011 to June 2014 were selected. According to the random number table method, there were 21 cases in the observation group and 21 cases in the control group. There were 14 males and 7 females in the control group, with an average age of 52.77 卤6.11 years, 15 males and 6 females in the observation group. The average age was 53.15 卤5.47 years old. The control group was treated with 5-fluorouracil combined with neidaplatin, and the observation group was treated with simultaneous intensity conformal radiotherapy of neidaplatin and docetaxel. The short-term remission rate and toxicity were compared between the two groups. Results the complete remission rate of the observation group was 71.43, and the short-term effective rate was 90.48. There was no significant difference between the observation group and the control group (蠂 2 complete remission rate was 0.891P 0.251; 蠂 2 short-term response rate was 0.922 P 0.185; the observation group had no significant difference between the control group and the control group before and after chemotherapy. The volume of gross tumor target was 49.21 卤6.15 cm ~ (3), 36.14 卤5.07 cm ~ (3), the volume reduction rate was 26.56, there was no significant difference between the two groups (P 0.05). The incidence of neutropenia, anorexia and abdominal distension was significantly lower than that of the control group (P 0.05). Conclusion docetaxel combined with intensity modulated conformal radiotherapy is effective in the treatment of locally advanced nasopharyngeal carcinoma. Toxicity and side effects are acceptable and worthy of clinical application.
【作者单位】：台州市肿瘤医院肿瘤内科;
【分类号】：R739.63

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