眼睑基底细胞癌组织中基质金属蛋白酶-2、基质金属蛋白酶-7的表达

发布时间：2018-03-31 21:49

本文选题：眼睑基底细胞癌　切入点：基质金属蛋白酶-　出处：《肿瘤基础与临床》2016年06期

【摘要】：目的探讨眼睑基底细胞癌组织中基质金属蛋白酶-2(MMP-2)、MMP-7的表达及其临床意义。方法采用免疫组化S-P法检测50例眼睑基底细胞癌和20例眼睑松弛症组织中MMP-2、MMP-7的表达水平,并分析两者与眼睑基底细胞癌临床病理参数的关系。结果眼睑基底细胞癌组织中MMP-2、MMP-7的阳性率分别为76.0%(38/50)、78.0%(39/50),均高于眼睑松弛症组织的10.0%(2/20)、15.0%(3/20)(P均0.05)。眼睑基底细胞癌组织中MMP-2、MMP-7的表达均与患者的肿瘤直径、TNM分期及有无脉管浸润有关(P0.05)。眼睑基底细胞癌组织中MMP-2、MMP-7的表达呈正相关关系(r=0.493,P0.05)。结论眼睑基底细胞癌组织中MMP-2、MMP-7的表达明显升高,两者可能协同促进眼睑基底细胞癌的发生、发展。
[Abstract]:Objective to investigate the expression and clinical significance of matrix metalloproteinase-2 (MMP) -2m-2 + -mMMP-7 in eyelid basal cell carcinoma (BCC). Methods Immunohistochemical S-P method was used to detect the expression of MMP-2MMP 7 in 50 cases of eyelid basal cell carcinoma (BCC) and 20 cases of blepharolacia. Results the positive rate of MMP-2MMP-7 in BCC tissues was 76.0% 3850% and 78.0% respectively, which was higher than that in blepharolacia tissues (10.0% 20%, 15.0%, 0.05%, P = 0.05). The expression of MMP-2 and MMP-7 in eyelid basal cell carcinoma tissues was significantly higher than that in blepharolacia tissues (10.0% 20%, 15.0%, 0.05%, P = 0.05), respectively. The positive rates of MMP-2 and MMP-7 in eyelid basal cell carcinoma were 78.0% and 78.0%, respectively, which were higher than those in blepharolacia tissues. The expression of MMP-2 and MMP-7 was positively correlated with TNM stage and vascular infiltration in patients with BCC. Conclusion the expression of MMP-2 and MMP-7 in BCC is significantly higher than that in BCC. Both of them may promote the occurrence and development of basal cell carcinoma of eyelid.
【作者单位】：河南省军区医院眼科;
【分类号】：R739.71

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