鼻腔鼻咽部淋巴瘤:319例会诊病例分析

发布时间：2018-04-05 21:21

  本文选题：鼻腔鼻咽部淋巴瘤　切入点：弥漫大B细胞淋巴瘤　出处：《临床与实验病理学杂志》2017年11期

【摘要】：目的探讨鼻腔鼻咽部淋巴瘤的临床特点、病理分型及类型构成。方法回顾性分析首都医科大学附属北京友谊医院病理科319例鼻腔鼻咽部淋巴瘤会诊病例的临床资料、病理组织学特征及免疫表型,按WHO(2008)分类标准进行病理诊断及分类,并对统计结果进行对比分析。结果 319例会诊病例中,3例(0.9%)诊断为霍奇金淋巴瘤混合细胞型,考虑肿瘤累及鼻咽,建议全身检查;316例均为非霍奇金淋巴瘤(99.1%),包含非霍奇金T和NK细胞起源淋巴瘤177例(56.0%)、B细胞起源淋巴瘤139例(44.0%)。发病率位于前两位的是NK/T细胞淋巴瘤鼻型160例(50.6%)、弥漫大B细胞淋巴瘤64例(20.3%)。NK/T细胞淋巴瘤发病率高于弥漫大B细胞淋巴瘤。≥60岁的患者106例(33.2%)诊断均为非霍奇金淋巴瘤,其中弥漫大B细胞淋巴瘤40例(37.7%)、NK/T细胞淋巴瘤36例(34.0%),弥漫大B细胞淋巴瘤与NK/T细胞淋巴瘤发病率无统计学意义。60岁的非霍奇金淋巴瘤患者210例(66.5%),其中NK/T细胞淋巴瘤124例(59.0%)、弥漫大B细胞淋巴瘤24例(11.4%),发病率差异有显著性。结论 316例鼻腔鼻咽部非霍奇金淋巴瘤中以NK/T细胞淋巴瘤最为多见,第二位是弥漫大B细胞淋巴瘤;≥60岁老人鼻腔鼻咽部淋巴瘤患者弥漫大B细胞淋巴瘤、NK/T细胞淋巴瘤最为多见,两者之间发病率差异无显著性。
[Abstract]:Objective to investigate the clinical features, pathological types and types of nasopharyngeal lymphoma.Methods the clinical data, histopathological features and immunophenotype of 319 cases of nasopharyngeal lymphoma in the Department of Pathology of Beijing Friendship Hospital affiliated to Capital Medical University were retrospectively analyzed.The statistical results are compared and analyzed.Results among 319 consultation cases, 3 cases were diagnosed as Hodgkin's lymphoma mixed cell type, and the tumor was involved in nasopharynx.It was suggested that all 316 cases of non-Hodgkin 's lymphoma should be diagnosed as non-Hodgkin 's lymphoma and 99.1%, which included 177 cases of non-Hodgkin 's T and NK cell derived lymphoma (n = 177). 139 cases of B cell derived lymphoma (n = 139) were from B cell origin lymphoma.The incidence of NK-T cell lymphoma was higher in 64 cases of diffuse large B-cell lymphoma than that of diffuse large B-cell lymphoma. The incidence of NK-P T cell lymphoma was higher than that of diffuse large B-cell lymphoma. 106 patients over 60 years of age were diagnosed as non-Hodgkin 's lymphoma.124 cases (59.0%) and 24 cases (11.4%) diffuse large B-cell lymphoma (DSLL) had significant difference in incidence.Conclusion among 316 cases of nasopharyngeal non-Hodgkin 's lymphoma, NK/T cell lymphoma is the most common, the second is diffuse large B cell lymphoma.NK / T cell lymphoma was the most common in patients with nasal and nasopharyngeal lymphoma (鈮，

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