PDR患者玻璃体中VEGF、CTGF含量及其相关性研究

发布时间：2018-04-06 02:38

本文选题：PDR　切入点：VEGF和CTGF含量　出处：《皖南医学院》2017年硕士论文

【摘要】：目的:研究PDR(增殖性糖尿病视网膜病变)患者玻璃体中VEGF(血管内皮生长因子)、CTGF(结缔组织生长因子)含量及其相关性,以探讨VEGF和CTGF对PDR病程发生发展的影响。方法:收集淮南市第一人民医院眼科2015年9月至2016年9月,因PDR IV~VI期行玻璃体切除手术的患者21例21眼玻璃体为PDR组,因视网膜脱离、眼外伤或晶体脱入玻璃体行玻璃体切除手术的患者12例12眼玻璃体为对照组。采用双抗体夹心酶联免疫吸附试验(ELISA)方法分别测定PDR组和对照组玻璃体中VEGF、CTGF的浓度,并进行组间比较,所得数据采用SPASS17.0统计软件分析。结果:PDR组VEGF含量(147.24±42.43pg/ml)明显高于对照组(57.98±17.06pg/ml),PDR组CTGF含量(1188.06±233.38ng/ml)高于对照组为(684.21±199.33ng/ml),二者均有显著统计学意义(P0.01)。但PDR组VEGF与CTGF含量相关性不显著(P0.05)。结论:增殖性糖尿病视网膜病变组患者的VEGF和CTGF水平均高于对照组患者,提示VEGF、CTGF共同参与了增殖性糖尿病视网膜病变的发生和发展,抗CTGF可能将成为治疗PDR新靶点。
[Abstract]:Aim: to study the content and correlation of vascular endothelial growth factor (VEGF) in vitreous of patients with proliferative diabetic retinopathy (PDR), and to investigate the effect of VEGF and CTGF on the development of PDR.Methods: from September 2015 to September 2016, 21 cases (21 eyes) of PDR IV~VI underwent vitrectomy in Huainan first people's Hospital from September 2015 to September 2016, and 21 eyes of vitreous body were divided into PDR group and retinal detachment group.Vitrectomy was performed in 12 patients with ocular trauma or vitrectomy.The concentrations of VEGF CTGF in vitreous of PDR group and control group were determined by Elisa. The data were compared with each other. The data were analyzed by SPASS17.0 software.Results the VEGF content in the control group (147.24 卤42.43 PG / ml) was significantly higher than that in the control group (57.98 卤17.06 PG / ml), and the CTGF content in the control group was 1188.06 卤233.38 ng / ml, which was significantly higher than that in the control group (684.21 卤199.33 ng / ml).However, there was no significant correlation between VEGF and CTGF content in PDR group (P 0.05).Conclusion: the levels of VEGF and CTGF in proliferative diabetic retinopathy group are higher than those in control group, suggesting that VEGF CTGF is involved in the occurrence and development of proliferative diabetic retinopathy, and anti CTGF may be a new target for the treatment of PDR.
【学位授予单位】：皖南医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2;R774.1

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