肿瘤相对体积对局部晚期鼻咽癌的预后影响

发布时间：2018-04-11 16:29

本文选题：鼻咽癌 + 肿瘤相对体积　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:探讨肿瘤相对体积对接受同步调强放化疗的局部晚期鼻咽癌患者的预后影响。材料与方法:2009年1月1日至2012年12月30日期间经广西医科大学第一附属医院放疗科病理确诊的初治鼻咽癌的患者143例入组本组研究。所有患者均为III IVb期(UICC分期),均接受调强放疗+同步化疗。肿瘤体积由计划系统三维重建并自动计算。总肿瘤相对体积(RGTV)=总肿瘤体积(GTV)/人体体积,原发鼻咽部肿瘤相对体积(RGTVnx)=原发鼻咽部肿瘤体积(GTVnx)/人体体积,转移淋巴结相对体积(RGTVnd)=转移淋巴结体积(GTVnd)/人体体积。结果:RGTV、RGTVnx,RGTVnd的截点分别为2.38、1.091、0.273。RGTV2.38 vs RGTV≤2.38两组患者5年总生存率、无瘤生存率、无远处转移生存率、无复发生存率分别为46.1%与95.8%(P0.001),42.5%与97.0%(P0.001)、52.8%与98.0%(P0.001),72.7%与98.0%(P0.001)。RGTVnx1.091与RGTVnx≤1.091两组患者5年总生存率、无病生存率、无远处转移生存率、无复发生存率分别为65.4%与93.4%(P0.001),65.2%与94.8%(P0.001)、71.4%与97.4%(P0.001),84.8%与97.3%(P=.003),RGTVnd0.273与RGTVnd≤0.273两组的患者的5年总生存率、无病生存率、无远处转移生存率、无复发生存率分别为70.3%与96.5%(P0.001),70.1%与94.8%(P0.001),77.5%与98.2%(P0.001),88.5%与96.6%(P=0.049)。结论:肿瘤相对体积是鼻咽癌的独立预后因素。
[Abstract]:Objective: to investigate the effect of tumor relative volume on prognosis of locally advanced nasopharyngeal carcinoma (NPC) patients undergoing synchronous intensity modulated radiotherapy and chemotherapy.Materials and methods: from January 1, 2009 to December 30, 2012, 143 patients with nasopharyngeal carcinoma (NPC) diagnosed pathologically in the Department of radiotherapy of the first affiliated Hospital of Guangxi Medical University were enrolled in this study.All the patients were treated with intensity modulated radiotherapy (IMRT) combined with chemotherapy.Tumor volume is reconstructed by the three-dimensional planning system and calculated automatically.The relative volume of primary nasopharynx neoplasms is the volume of primary nasopharyngeal tumor, the volume of primary nasopharynx tumor is GTVnxX / human body volume, the relative volume of metastatic lymph node is RGTVndD = the volume of metastatic lymph node is GTVndT / human body volume, the relative volume of primary nasopharyngeal tumor is the same as the volume of primary nasopharynx tumor and the relative volume of metastatic lymph node is equal to the volume of metastatic lymph node.The recurrence free survival rate was 70.3% and 96.5%, respectively, and 70.1% and 94.8%, respectively, and 77.5% and 98.2% respectively.Conclusion: tumor relative volume is an independent prognostic factor for nasopharyngeal carcinoma.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R739.63

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