肝细胞生长因子在OSAHS患者血清中的表达及意义

发布时间：2018-04-15 04:34

本文选题：肝细胞生长因子 + 睡眠呼吸暂停低通气综合征　；参考：《临床耳鼻咽喉头颈外科杂志》2017年09期

【摘要】：目的:探讨OSAHS患者外周血肝细胞生长因子(HGF)的检测及其意义。方法:选择96例OSAHS患者作为OSAHS组,根据鼾症程度分为轻、中、重3组,每组32例;以体检科35例正常人作为对照组。采用ELISA法测定血清HGF浓度,32例重度OSAHS患者综合治疗3个月,复测HGF浓度,分析血清HGF与睡眠呼吸事件各指标的相关性。结果:外周血HGF浓度随OSAHS患者病情严重程度呈递增趋势,对照组与轻、中、重组血清HGF水平分别为(487.75±46.74)pg/ml、(519.44±50.77)pg/ml、(753.52±58.91)pg/ml、(829.49±61.74)pg/ml,组间相互比较均差异有统计学意义(F=117.733,P0.01);OSAHS患者外周血HGF水平和年龄、性别、BMI无关(P0.05),与AHI呈正相关(P0.01),与LSaO2呈负相关(P0.01);32例重度OSAHS患者综合治疗后血清HGF水平及AHI较治疗前下降,LSaO2上升,差异有统计学意义(P0.01)。结论:OSAHS患者体内HGF水平升高,与其病情严重程度呈正相关,测定外周血HGF水平对判断OSAHS病情严重程度和血管内皮功能损害程度、评估患心血管疾病的风险性具有一定的临床意义。
[Abstract]:Objective: to investigate the significance of detection of hepatocyte growth factor (HGF) in peripheral blood of patients with OSAHS.Methods: 96 patients with OSAHS were selected as OSAHS group. According to the degree of snoring, 32 patients in each group were divided into three groups: mild, moderate and heavy, and 35 normal subjects as control group.The serum HGF concentration was measured by ELISA method in 32 patients with severe OSAHS for 3 months. The HGF concentration was measured again and the correlation between serum HGF and sleep respiratory events was analyzed.Results: the level of HGF in peripheral blood increased with the severity of OSAHS. In the control group and mild group, the level of HGF in the recombinant serum was 519.44 卤50.77pg / ml, which was 519.44 卤50.77pg / ml, respectively. There were significant differences between the two groups in the level of HGF and the age of the patients with OSAHS.The serum HGF level and AHI level in 32 patients with severe OSAHS after comprehensive treatment were significantly lower than those before treatment, and the difference was statistically significant (P 0.01).Conclusion there is a positive correlation between the level of HGF and the severity of the disease in the patients with OSAHS. The level of HGF in peripheral blood can be used to judge the severity of OSAHS and the degree of vascular endothelial function damage.It is of clinical significance to evaluate the risk of cardiovascular disease.
【作者单位】：郏县人民医院呼吸内科;河南省中医院呼吸科;平顶山市第一人民医院呼吸内科;
【分类号】：R766

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