奥美拉唑联合四君子汤治疗咽喉反流60例临床观察

发布时间：2018-04-15 18:00

  本文选题：咽喉反流 + 奥美拉唑　； 参考：《辽宁中医药大学》2012年硕士论文

【摘要】：目的：对于咽喉反流的患者通常以质子泵抑制剂与促胃动力药作为首选药物进行治疗。但随着临床实践的不断深入,发现质子泵抑制剂有剂量不易掌握,长期使用易出现负作用等缺点,且其对某些咽喉反流患者无效。这就需要我们探索治疗咽喉反流新的出路。目前中医界对于咽喉反流的研究虽尚不完善,但根据其辨证论治的特点应用中药汤剂对咽喉反流进行治疗具有巨大的潜力。本实验研究的目的为观察与确认奥美拉唑联合中药四君子汤治疗咽喉反流的临床疗效,探讨其治疗咽喉反流的部分作用机理。 材料与方法：选择符合试验标准的咽喉反流患者60名,随机分为观察组与对照组各30例。治疗组为应用奥美拉唑及多潘立酮联合中药四君子汤治疗：对照组为单纯应用西药奥美拉唑和多潘立酮治疗。治疗三个月后进行随访。通过比对患者治疗前后的反流症状指数量表(RSI)以评估治疗效果。RSI评分下降值7为显效,下降值4分但≤7分为有效,≤4分为无效。 结果：奥美拉唑联合四君子汤治疗组疗效明显优于口服奥美拉唑和多潘立酮对照组,两组总有效率(显效+有效)差异具有统计学意义(P0.05) 结论：奥美拉唑联合中药四君子汤治疗咽喉反流疗效优于单纯应用奥美拉唑与多潘立酮。
[Abstract]:Objective: proton pump inhibitors and gastric motility drugs are the first choice for patients with pharynx and larynx reflux.However, with the deepening of clinical practice, proton pump inhibitors are found to be difficult to grasp the dose, long-term use is prone to negative effects, and it is ineffective for some patients with pharynx and throat reflux.This requires us to explore a new way to treat throat reflux.Although the research on pharynx and larynx reflux in Chinese medicine is not perfect, it has great potential to treat throat reflux with traditional Chinese medicine decoction according to its characteristics of syndrome differentiation.The purpose of this study was to observe and confirm the clinical efficacy of omeprazole combined with Sijunzi decoction in the treatment of throat reflux and to explore the mechanism of its treatment.Materials and methods: 60 patients with pharynx and larynx reflux were randomly divided into two groups: the observation group (n = 30) and the control group (n = 30).The treatment group was treated with omeprazole and domperidone combined with Sijunzi decoction and the control group was treated with omeprazole and domperidone.The patients were followed up for 3 months.By comparing the reflux symptom index (RSII) before and after treatment, we evaluated the therapeutic effect. The RSI score decreased by 7, the drop value was 4 but 鈮，

本文编号：1755184