鼻咽癌根治性放疗后发生远处转移患者的预后及其影响因素分析

发布时间：2018-04-17 00:18

本文选题：鼻咽肿瘤 + 预后　；参考：《重庆医学》2017年36期

【摘要】：目的研究鼻咽癌根治性放疗后发生远处转移患者的预后并分析其影响因素。方法随访150例鼻咽癌根治性放疗后发生远处转移的患者,采集其临床数据进行预后分析及影响因素分析。结果随访患者的中位生存时间为13.50个月,1年生存率49.8%,2年生存率31.0%,3年生存率19.3%。Cox模型单因素分析结果表明初诊N分期、初诊是否化疗、完成放疗到发生远处转移的时间间隔、转移部位、发生远处转移后化疗与否及化疗期数、是否进行姑息性放疗为预后相关影响因素(均P0.05),其中初诊N分期、转移部位、发生远处转移后化疗与否、完成放疗到发生远处转移的时间间隔、是否进行姑息性放疗为预后的独立影响因素(均P0.05)。结论鼻咽癌根治性放疗后发生远处转移患者预后的独立影响因素有初诊N分期、转移部位、发生远处转移后化疗与否、完成放疗到发生远处转移的时间间隔、是否进行姑息性放疗。
[Abstract]:Objective to study the prognosis of patients with distant metastasis after radical radiotherapy of nasopharyngeal carcinoma (NPC) and analyze its influencing factors.Methods 150 patients with distant metastasis after radical radiotherapy of nasopharyngeal carcinoma were followed up and their clinical data were collected for prognostic analysis and analysis of influencing factors.Results the median survival time was 13.50 months, the 1-year survival rate was 49.8, and the 2-year survival rate was 31.0. The results of univariate analysis of the 3-year survival rate 19.3%.Cox model showed that the first diagnosed N stage, whether the first visit was chemotherapy or not, and the time interval between radiotherapy and distant metastasis were completed.Metastasis site, chemotherapeutic period after distant metastasis, palliative radiotherapy were the prognostic factors (all P 0.05). Among them, N stage, metastasis site, chemotherapy after distant metastasis or not,The interval between complete radiotherapy and distant metastasis, palliative radiotherapy was an independent prognostic factor (all P 0.05).Conclusion the independent factors influencing the prognosis of patients with distant metastasis after radical radiotherapy of nasopharyngeal carcinoma are N staging, location of metastasis, chemotherapy after distant metastasis, and the time interval between radiotherapy and distant metastasis.Whether or not to receive palliative radiotherapy.
【作者单位】：江苏大学医学院;江苏省宜兴市肿瘤医院放疗科;江苏省宜兴市肿瘤医院外科;
【基金】：国家杰出青年科学基金项目(H0203) 吴阶平医学基金会临床科研专项资助基金项目(320.6750.11088)
【分类号】：R739.63

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