嗓音障碍严重指数在咽喉反流相关嗓音疾病中的应用研究

发布时间：2018-04-17 12:54

本文选题：咽喉反流 + 嗓音疾病　；参考：《临床耳鼻咽喉头颈外科杂志》2017年22期

【摘要】：目的:探讨嗓音障碍严重指数(DSI)在咽喉反流(LPR)相关嗓音疾病诊疗评价中的有效性和可靠性。方法:选取2016-01-2017-06期间就诊的嗓音疾病伴有LPR并确诊的患者54例,根据是否接受手术治疗分为手术组和非手术组。手术组(32例)接受激光手术和规范抑酸治疗6周;非手术组(22例)接受规范抑酸治疗6周。治疗前后分别进行24h多通道腔内阻抗-pH监测、反流症状指数评分(RSI)、反流体征指数评分(RFS)、主观听感知评估和嗓音客观声学参数检测并计算嗓音障碍严重指数进行分析。结果:2组患者年龄、性别和病程均差异无统计学意义(P0.05);与治疗前比较,2组治疗后RSI、RFS、Jitter、Shimmer、G值和R值明显降低(P0.05),MPT和DSI明显升高(P0.05);手术组在治疗前RSI、RFS、Jitter、Shimmer、G值和R值明显高于非手术组(P0.05),MPT和DSI值明显低于非手术组(P0.05);2组治疗后各项参数差异无统计学意义(P0.05);DSI与Jitter、Shimmer、G值、R值呈负相关(P0.01);与RSI、RFS、MPT呈正相关(P0.01);与病变部位有关(P0.05)。结论:DSI可以作为对LPR相关嗓音疾病的诊断和治疗效果进行客观评价的指标,准确可靠。
[Abstract]:Objective: to investigate the effectiveness and reliability of DSI in the diagnosis and treatment of voice diseases associated with larynx reflux syndrome (LPRR).Methods: a total of 54 patients with voice disease accompanied with LPR were selected from 2016-01-2017-06 and were divided into operative group and non-operative group according to whether they received surgical treatment or not.The operation group (n = 32) received laser surgery and regular acid suppression for 6 weeks, and the non-operative group (n = 22) received standard acid suppression for 6 weeks.Before and after treatment, 24 h multichannel intracavitary impedance pH monitoring, reflux symptom index score (RSI), reflux sign index score (RFSN), subjective auditory perception assessment, voice objective acoustic parameters detection and analysis were performed.Results the age of the two groups of patients,There was no significant difference in sex and course of disease between the two groups (P 0.05); compared with before treatment, the value of RSI RFSs Jitterus ShimmerG and R decreased significantly after treatment, and the values of MPT and DSI increased significantly in the operation group, and the values of RSI SRFSRFSJitterShimmerG and R in the operation group were significantly lower than those in the non-operative group (P 0.05 MPT and R).There was no significant difference in the parameters between the two groups after treatment. There was a negative correlation between DSI and Jitterus ShimmerG value (P 0.01), a positive correlation with RSI RFSU MPT (P 0.01), and a positive correlation with the lesion site (P 0.05).ConclusionDSI can be used as an objective evaluation index for the diagnosis and treatment of LPR related voice diseases, and it is accurate and reliable.
【作者单位】：北京大学深圳医院耳鼻咽喉科;北京大学深圳医院口腔科;
【基金】：深圳市卫生计生系统科研项目(No:201607002)
【分类号】：R767.92

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