2型糖尿病合并皮质性白内障患者房水中Txnip、Trx的定量检测及相关性分析

发布时间：2018-04-18 14:05

  本文选题：糖尿病性白内障 + 硫氧还蛋白　； 参考：《眼科新进展》2017年08期

【摘要】：目的探讨2型糖尿病合并皮质性白内障的患者房水中硫氧还蛋白(thioredoxin,Trx)、硫氧还蛋白互作蛋白(thioredoxin interacting protein,Txnip)的含量以及与皮质性白内障程度的相关性。方法采用酶联免疫吸附实验(ELISA法)测定60例(60眼)明确诊断2型糖尿病合并皮质性白内障患者的房水中Trx及Txnip的含量,其中按照患者糖化血红蛋白(hemoglobin A1c,HbA1c)值将患者分组:A组(对照组,20例)HbA1c5.5%;B组(20例)5.5%≤HbA1c6.5%和C组(20例)HbA1c≥6.5%。结果与A组相比,B组患者房水中Txnip浓度增高,而C组浓度最高,差异均有统计学意义(均为P0.05);与A组相比,B组Trx的浓度升高,而C组Trx的浓度最低,差异均有统计学意义(均为P0.05)。A组中Trx与Txnip的浓度呈正相关(r=0.810,P=0.000);在C组中,Trx与Txnip的浓度呈负相关(r=-0.809,P=0.000),与白内障程度呈负相关(r=-0.727,P=0.001),其余均不相关(均为P0.05)。Logistic回归分析显示,Txnip和HbA1c是白内障发病的危险因素。结论Trx、Txnip可能参与了糖尿病患者中白内障的发生发展。
[Abstract]:Objective to investigate the content of thioredoxin interacting protein Txnipp in aqueous humor of patients with type 2 diabetes mellitus complicated with cortical cataract and its correlation with the degree of cortical cataract.Methods the contents of Trx and Txnip in aqueous humor of 60 patients with type 2 diabetes mellitus complicated with cortical cataract were determined by enzyme-linked immunosorbent assay (Elisa).According to the HbA1HbA1cvalue of the patients, the patients were divided into two groups: group A (control group, 20 cases) and group B (20 cases with HbA1c5.5% 鈮，

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