糖皮质激素及银杏叶提取物治疗上呼吸道感染后嗅觉障碍临床效果观察

发布时间：2018-04-20 06:20

本文选题：上呼吸道感染后嗅觉障碍 + 糖皮质激素　；参考：《临床耳鼻咽喉头颈外科杂志》2017年20期

【摘要】：目的:观察银杏叶提取物联合醋酸泼尼松对上呼吸道感染后嗅觉障碍(PVOD)患者的临床治疗效果。方法:将42例明确上呼吸道感染后出现嗅觉障碍,同时排除鼻腔阻塞因素的患者随机分为两组,分别给予醋酸泼尼松和醋酸泼尼松联合银杏叶提取物治疗,在治疗前及治疗后1~3个月分别行TT嗅觉测试和Sniffin Sticks嗅觉测试,将治疗前后嗅觉功能测试结果进行统计分析。结果:20例PVOD患者经过醋酸泼尼松治疗,TT嗅觉测试结果显示5例(25.00%)患者嗅觉功能恢复正常,9例(45.00%)改善;Sniffin Sticks嗅觉测试结果显示4例(20.00%)患者嗅觉功能恢复正常,10例(50.00%)改善。22例PVOD患者加用银杏叶提取物治疗,TT嗅觉测试结果显示7例(31.82%)患者嗅觉功能恢复正常,11例(50.00%)改善;Sniffin Sticks嗅觉测试结果显示6例(27.27%)患者嗅觉功能恢复正常,12例(54.55%)改善。结论:醋酸泼尼松和醋酸泼尼松联合银杏叶提取物对PVOD有治疗效果。两种方案的治疗效果虽在统计学上无明显差异,但联合银杏叶提取物的治疗效果有好于单独使用醋酸泼尼松的趋势。治疗时间延长有助于嗅觉功能的恢复。
[Abstract]:Objective: to observe the clinical effect of ginkgo biloba extract combined with prednisone acetate on patients with olfactory disorder PVODs after upper respiratory tract infection. Methods: Forty-two patients with olfactory disorder after upper respiratory tract infection were randomly divided into two groups: prednisone acetate and prednisone acetate combined with ginkgo biloba extract. TT olfactory test and Sniffin Sticks olfactory test were performed before treatment and 1 ~ 3 months after treatment. The results of olfactory function test before and after treatment were statistically analyzed. Results the olfactory test of 20 cases of PVOD treated with prednisone acetate showed that 5 cases had normal olfactory function, 9 cases had normal olfactory function and 9 cases had normal olfactory function. The results of olfactory test showed that 4 cases had normal olfactory function and 10 cases had normal olfactory function. The results of olfactory test of 22 patients with PVOD treated with Ginkgo biloba extract showed that 7 cases (31.82%) had normal olfactory function and 11 cases had normal olfactory function. The results of olfactory test showed that 6 cases (27.2727) patients had normal olfactory function and 12 cases (54.55%) had improved olfactory function. Conclusion: prednisone acetate and prednisone acetate combined with ginkgo biloba extract have therapeutic effect on PVOD. Although there was no statistical difference between the two schemes, the therapeutic effect of Ginkgo biloba extract combined with Ginkgo biloba extract was better than that of prednisone acetate alone. Prolonged treatment is helpful to the recovery of olfactory function.
【作者单位】：首都医科大学附属北京安贞医院耳鼻咽喉头颈外科;
【基金】：国家自然基金项目(No:81670903)
【分类号】：R56;R765

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