球后脂肪体积测定对甲状腺相关性眼病治疗时机的判定价值

发布时间：2018-04-21 02:26

本文选题：thyroid-associated + ophthalmopathy　；参考：《南方医科大学学报》2017年05期

【摘要】：目的探讨商业化软件计算球后脂肪体积,分析其与甲状腺相关性眼病(TAO)进展及预后的关系。方法收集2016年1月~2016年12月在我院内分泌科确诊的35例(70个眼眶)TAO患者的临床资料。测量1.5T眼眶MRI球后脂肪体积及眼外肌信号强度比值(SIR)分析其与临床各项指标的相关性,并收集12例(24个眼眶)健康人测量球后脂肪体积,初步比较TAO组及健康组体积的差异。结果脂肪体积与病程成正相关(r=0.480,P0.01),病程6个月以内组与6~12个月组相比,脂肪体积差异不显著(P=0.084)。病程6个月以内组及病程6~12个月组球后脂肪体积均显著低于病程大于12个月组(P0.01,P0.05)。脂肪体积与突眼度存在相关性(r=0.622,P0.01),突眼度每增加1 mm,球后脂肪体积将增加0.88 m L。临床活动性评分(CAS)与SIR值及促甲状腺素受体抗体(TRAb)存在相关性(r=0.536,r=0.416,P0.01)。TAO组球后脂肪体积显著高于正常组(P0.01)。结论 TAO病程1年以上可能是球后脂肪组织增多的高峰阶段,球后脂肪体积结合SIR值的测量有助于最佳激素治疗时机的探索及预后分析。
[Abstract]:Objective to investigate the relationship between retrobulbar fat volume and the progression and prognosis of thyroid associated ophthalmopathy (TAO) by commercial software. Methods from January 2016 to December 2016, the clinical data of 35 cases (70 cases of orbital TAO) diagnosed in the department of endocrine department in our hospital were collected. Retrobulbar fat volume and signal intensity ratio of extraocular muscle (EOMG) were measured at 1.5T. The correlation between the volume of fat and clinical indexes was analyzed. Twelve healthy subjects (24 eyes) were collected to measure the volume of retrobulbar fat, and the difference between TAO group and healthy group was preliminarily compared. Results there was a positive correlation between the fat volume and the course of the disease. There was no significant difference in fat volume between the 6 month group and the 6 ~ 12 month group. The volume of retroglobular fat in 6 months group and 6 ~ 12 month group was significantly lower than that in longer than 12 month group. There was a correlation between the volume of fat and the degree of exophthalmos. The volume of fat behind the ball increased by 0.88 mL with the increase of 1 mm in the degree of exophthalmos. There was a significant correlation between clinical activity score and SIR and thyrotropin receptor antibody (TRAb). The volume of retroglobular fat in the TAO group was significantly higher than that in the normal group (P 0.01). Conclusion the course of TAO for more than one year may be the peak stage for the increase of retrobulbar adipose tissue. The measurement of retrobulbar fat volume combined with SIR value may be helpful to explore the best time of hormone therapy and to analyze the prognosis.
【作者单位】：南方医科大学第三附属医院内分泌与代谢科;
【基金】：南方医科大学“临床科研启动计划”(LC2016PY046)
【分类号】：R581;R771.3

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