12例眼眶孤立性纤维性肿瘤临床病理特征分析

发布时间：2018-04-21 23:33

本文选题：眶肿瘤 + 孤立性纤维性肿瘤　；参考：《天津医科大学学报》2016年01期

【摘要】：目的:探讨眼眶孤立性纤维性肿瘤的临床、影像、组织病理学特征及治疗方法。方法:回顾分析经手术治疗的12例眼眶孤立性纤维性肿瘤病例的基本临床资料和组织石蜡标本,研究该类肿瘤的临床及组织病理学特点。结果:12例患者中,男性8例,女性4例;就诊年龄为30~60岁;病程为2个月~12年;4例主诉眼球突出,4例主诉眼睑肿胀,4例主诉发现肿物。病变位于右眼眶内7例,左眼眶内5例;彩色超声多普勒检查显示多为眶内边界清楚的均匀或不均匀中低回声区,病变区多可见丰富的红蓝血流信号。CT检查肿瘤多为边界清楚的实质性占位影,可被造影剂强化。组织病理学检查显示肿瘤细胞主要由梭形或卵圆形细胞组成,肿瘤细胞无明显异形性,其间有胶原纤维和大量树枝状或鹿角状血管。免疫组织化学染色结果:CD34、波形蛋白抗体多为弥漫阳性表达。结论:孤立性纤维性肿瘤的临床及影像学表现无显著特异性,易与其他肿瘤混淆。结合临床资料进行组织病理学及免疫组织化学检查,可作为其定性诊断的重要依据。该肿瘤治疗以手术完整切除为主。应注意密切随访。
[Abstract]:Objective: to investigate the clinical, imaging, histopathological features and treatment of orbital solitary fibrous tumors. Methods: the basic clinical data and paraffin wax specimens of 12 cases of orbital solitary fibrous tumors were retrospectively analyzed. The clinical and histopathological characteristics of these tumors were studied. Results among 12 cases, 8 cases were male and 4 cases were female, the age was 30 ~ 60 years old, the course of disease was 2 months ~ 12 years, 4 cases had main complaint of exophthalmos, 4 cases complained of swelling of eyelid. The lesions were located in 7 cases in the right orbit and 5 cases in the left orbit. There were abundant red and blue blood flow signals in the lesion area. Ct examination showed that most tumors were solid space occupying shadow with clear boundary, which could be enhanced by contrast medium. Histopathological examination showed that the tumor cells were mainly composed of fusiform or oval cells. There was no obvious heteromorphism in the tumor cells. There were collagen fibers and a large number of dendritic or antler vessels in the tumor cells. Immunohistochemical staining showed that most vimentin antibodies were diffusely positive. Conclusion: the clinical and imaging findings of solitary fibrous tumors are not specific and easy to be confused with other tumors. Histopathology and immunohistochemical examination combined with clinical data can be used as an important basis for qualitative diagnosis. The tumor was treated mainly by complete resection. Attention should be paid to close follow-up.
【作者单位】：天津医科大学眼科临床学院;天津市眼科医院天津市眼科学与视觉科学重点实验室天津市眼科研究所;
【分类号】：R739.72

【相似文献】