新生血管性青光眼抗VEGF联合手术治疗的Meta分析

发布时间：2018-04-22 12:54

本文选题：抗VEGF + 新生血管性青光眼　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:评估抗VEGF药物玻璃体腔注射辅助青光眼Ahmed减压阀植入术对新生血管性青光眼治疗效果的影响方法:检索国内外数据库,囊括以下数据库:Pubmed、The Cochrane Library、EMBASE、维普中文科技期刊数据库、中国知网、万方数据库,选取2017年1月1日前的文献,主题是关于新生血管性青光眼Ahmed减压阀植入术前或术中是否给予抗VEGF药物玻璃体腔注射的对照研究。纳入7篇文章,通过提取数据,应用Comprehensive Meta Analysis2.0软件,眼压下降幅度(基础眼压与观察终点的眼压之差)IOPR作为主要的评估指标,手术成功率的比值比(OR)及95%可信区间(confidence interval,CI)作为次要评估指标,并分析术后并发症。结果:本系统评价纳入七项研究,299例患者308只眼。Meta分析结果显示,抗VEGF药物玻璃体腔注射辅助青光眼Ahmed减压阀植入术与单纯Ahmed青光眼减压阀植入手术相比,降眼压作用稍强,术后1年眼压平均低4.182±1.765mm Hg(P0.05)。抗VEGF玻璃体腔注射辅助Ahmed青光眼减压阀植入术与Ahmed青光眼减压阀植入术相比,两组术后1年手术成功率的差异没有统计学意义。前者可以减少术后前房积血的发生。结论:抗VEGF药物玻璃体腔注射辅助Ahmed青光眼减压阀植入术与单纯Ahmed青光眼减压阀植入术相比,在降低眼压方面更为有效。两者在手术成功率方面的差异无统计学意义。抗VEGF药物的使用能减少术后前房积血的发生。
[Abstract]:Objective: to evaluate the effect of Ahmed pressure relief valve implantation on neovascular glaucoma with anti- VEGF drug intravitreal injection. Methods: to search the domestic and foreign databases, including the following databases: the Cochrane Library EMBASE, the Chinese Journal of Science and Technology database. China Zhiwang, Wanfang database, selected literature before January 1, 2017, the subject is whether to give intravitreal injection of anti- drugs before or during Ahmed pressure relief valve implantation in neovascular glaucoma. Seven articles were included, and the Comprehensive Meta Analysis2.0 software was used to extract the data. The decrease of IOP (the difference between the basic IOP and the IOP at the observation end point) was used as the main evaluation index. The ratio of success rate and 95% confidence interval (CI) were used as secondary evaluation indexes and postoperative complications were analyzed. Results: in this systematic evaluation, 308 eyes of 299 patients were included in this study. The results of Meta analysis showed that the intraocular pressure relief effect was slightly stronger than that of simple Ahmed glaucoma relief valve implantation, compared with that of Ahmed pressure relief valve implantation assisted by anti- VEGF drug intravitreal injection. The mean IOP was 4.182 卤1.765mm HgG P 0.05 after 1 year postoperatively. There was no significant difference in the postoperative success rate between the two groups in terms of anti- intravitreal injection assisted Ahmed glaucoma pressure relief valve implantation and Ahmed glaucoma pressure relief valve implantation. The former can reduce the incidence of postoperative hyphema. Conclusion: the anti- VEGF drug intravitreal injection assisted Ahmed glaucoma pressure relief valve implantation is more effective in reducing intraocular pressure than that of Ahmed glaucoma pressure relief valve implantation alone. There was no significant difference in surgical success rate between the two groups. The use of anti-VEGF drugs can reduce the incidence of postoperative hyphema.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R779.6

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