广域数字眼底成像关键技术研究

发布时间：2018-04-23 22:22

本文选题：早产儿视网膜病变 + 眼底相机　；参考：《南京航空航天大学》2017年硕士论文

【摘要】：正确观察并获取视网膜周边区域图像,可为早产儿视网膜病变(ROP)等多种眼科疾病的早期检测提供客观依据。传统眼底相机由于成像视场较小,需要患者高度配合,难以获取视网膜周边区域图像,无法应用于ROP等眼疾的早期检测。广域数字眼底成像系统可以观察视网膜周边区域并对其成像,为ROP等眼疾的早期检测和治疗提供更好的帮助。论文将重点研究便携式的广域数字眼底成像系统及其关键技术,为广域眼底数字成像系统的研制提供理论依据和实践指导。本论文主要研究内容如下:1.根据ROP等眼疾检测的要求,提出并研制了一种采用角膜接触透镜和环形分布光纤照明的便携式广域眼底成像系统,将广域眼底成像系统与Android终端通过WiFi传输模块相结合,广域眼底成像系统通过Android终端控制即可完成眼底图像的快速、实时采集,为ROP等眼疾提供客观的诊断依据。2.为模拟广域眼底成像系统的真实使用环境,根据人眼结构和各屈光介质光学参数建立了LIOU人眼模型。对人眼组织光谱特性和安全保护标准以及眼底相机工作原理进行研究,提出采用近红外光源作为成像系统的观察调焦光源,可见光作为成像系统的成像光源。3.根据理想物像关系建立了视场为45°的眼底正常视场成像光路,确定了成像光路的结构参数。通过分析计算得到采用同时移动成像物镜和图像探测器的调焦方式对不同屈光度(-10D~10D)人眼成像的调焦曲线图,在ZEMAX中模拟并分析了基于LIOU人眼模型的正常视场成像光路,可实现不同屈光度人眼的清晰成像。4.在正常成像视场光路的基础上引入非球面凹凸角膜接触透镜和环形光纤照明的方法实现视场为90°的眼底广域成像与照明,分析并解决了影响眼底广域成像的主要因素。使用ZEMAX和Lighttools分别对眼底广域成像与照明进行了模拟与分析,结果表明广域眼底成像系统满足使用要求。5.在Android SDK和索尼相机API的基础上完成了Android端视网膜成像系统软件的开发,将广域眼底成像系统与Android终端相结合搭建了一套便携式的视网膜成像系统,最终实现了便携式广域数字眼底成像系统。
[Abstract]:The correct observation and acquisition of peripheral retinal images can provide an objective basis for the early detection of various ophthalmic diseases such as retinopathy of preterm infants. Because of the small field of view, the traditional fundus camera needs the high cooperation of patients, so it is difficult to obtain the image of peripheral retinal area, and can not be used in the early detection of eye diseases such as ROP. Wide-area digital fundus imaging system can observe and image the peripheral area of the retina, and provide better help for the early detection and treatment of eye diseases such as ROP. This paper focuses on the portable wide-area digital fundus imaging system and its key technology to provide theoretical basis and practical guidance for the development of wide-area digital fundus imaging system. The main contents of this thesis are as follows: 1. According to the requirements of ROP and other ophthalmopathy detection, a portable wide-area fundus imaging system using corneal contact lens and ring distributed optical fiber illumination is proposed and developed. The wide-area fundus imaging system is combined with the Android terminal through the WiFi transmission module. The wide area fundus imaging system can complete the fast and real-time acquisition of fundus images through Android terminal control, and provide objective diagnostic basis for ROP and other eye diseases. In order to simulate the real operating environment of wide-area fundus imaging system, the LIOU human eye model was established according to the human eye structure and the optical parameters of various refractive media. The spectral characteristics and safety protection standards of human eye tissue and the working principle of fundus camera are studied. The near infrared light source is used as the observation focusing source of the imaging system, and the visible light source is used as the imaging light source of the imaging system. Based on the ideal image relationship, a normal field of view imaging light path with a field of view of 45 掳is established, and the structural parameters of the imaging light path are determined. By analyzing and calculating, the focusing curves of different diopters are obtained by using simultaneous moving objective lens and image detector. The normal field of view imaging light path based on LIOU human eye model is simulated and analyzed in ZEMAX. The clear imaging of human eyes with different diopters can be realized. 4. On the basis of normal field of view light path, the method of aspherical concave convex contact lens and annular optical fiber illumination is introduced to realize the wide area imaging and illumination of the eye ground with the field of view of 90 掳. The main factors affecting the wide area imaging of the eye ground are analyzed and solved. The wide-area imaging and illumination were simulated and analyzed by ZEMAX and Lighttools, respectively. The results show that the wide-area imaging system meets the requirement of .5. On the basis of Android SDK and Sony camera API, the software of Android retinal imaging system is developed. A portable retinal imaging system is built by combining wide-area fundus imaging system with Android terminal. Finally, the portable wide area digital fundus imaging system is realized.
【学位授予单位】：南京航空航天大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R770.4;TP311.52

【参考文献】