不同声刺激测试听觉事件相关电位的临床研究

发布时间：2018-04-26 04:16

本文选题：听觉事件诱发电位 + 汉语　；参考：《南方医科大学》2012年硕士论文

【摘要】：目的 1、采用不同刺激声(包括纯音、实意字、双音节词和数字)诱发听觉事件相关电位(auditory event-related potentials, AERP),探讨汉语言语声刺激的不同形式测试中国人AERP的可行性； 2、比较纯音和三种不同汉语言语刺激声在最适强度时诱发AERP波形,分析各波形中P3潜伏期及幅值差异,并对AERP波形进行量化评分,探讨刺激声与AERP波形的关系； 3、比较不同言语刺激声诱发AERP波形在单耳的差别,分析言语优势半球的特点,进一步探讨左右半球与不同言语处理过程的关系。方法根据我国汉语语言特点、言语测听及AERP测试声刺激的要求筛选出汉语单音节字、双音节词、数字表,将各表通过立体录音、剪辑、转换,编辑成与AERP测试软件相兼容的言语测试信号,随机选定靶刺激与非靶刺激,测试强度(感觉级)设置为60dB SL。分别采用不同的汉语言语(包括实意字、双音节词和数字)及纯音作为声刺激对正常青年人37名(70耳)进行AERP测试,对各组AERP波形进行标记并量化评分。比较言语和纯音刺激声诱发的AERP的潜伏期、幅值及波形评分在各组之间有无统计学差异；分析不同声刺激对P300的影响是否也存在于左右耳之间,比较纯音和三种不同汉语言语刺激声在最适强度时诱发的AERP波形在左右耳的差别,进一步探讨左右半球与不同言语处理过程的关系。结果不同汉语言语和纯音均可以记录到典型的AERP波形,且各组之间的P3引出率比较存在显著性差异(X2=9.046,P=0.029)。其中以双音节词刺激声最容易记录到,引出率为98.6%,与纯音组间比较差异具有统计学意义(X2=7.992,P=0.0050.05/6,6为比较次数),而其它组间比较AERP引出率无显著差异(P值均0.05)。各组P3波形量化评分及N2-P3振幅在不同刺激声之间的差异无明显统计学意义(前者F=1.795,P=0.496；后者F=0.800,P=0.496),但从整体来看,字和双音节词诱发的AERP波形较数字和纯音平滑,杂波少。不同刺激声组间P3的平均潜伏期有显著性差异(F=5.088,P=0.005),以数字组诱发的P3潜伏期最长,与其他三组比较差异均具有统计学意义(P值均0.05),而其它组间的P3潜伏期相比较则无明显差异(P值均0.05)。对四种不同刺激声测试时双耳均能记录到典型的AERP波形中N2潜伏期、P3潜伏期、N2-P3幅值分别进行单耳比较,发现左耳N2、P3平均潜伏期在不同组间均存在显著性差异(前者F=3.489,P=0.020；后者F=8.343,P=0.000)。右耳N2、P3平均潜伏期在四个组间差异无明显统计学意义(前者F=0.603,P=0.550；后者F=0.323,P=0.808),不同组间N2-P3幅值在单耳的比较亦无显著差异(左耳F=1.690,P=0.177；右耳F=1.644,P=0.187)。结论 1、除纯音和字外,汉语言语的其它形式,如双音节词、数字也适用于AERP测试刺激声的要求,可以得到满意的AERP波形,同样适合用于中国人的AERP测试,为言语测试AERP在临床上的进一步推广提供了一种适合中国人的更有实际意义的测试方法； 2、在最佳测试强度时,言语刺激声比纯音更容易记录到典型的AERP波形,其中以刺激声为双音节词较纯音更容易记录到； 3、从所有数据和波形可以看出,刺激声为字和双音节词时诱发的AERP波形较数字和纯音平滑,杂波少,波形更典型； 4、刺激声内容对P300潜伏期的影响有统计学意义,数字诱发的P3潜伏期较其它组明显延长,而对P300幅值的影响无统计学意义； 5、左耳记录到的AERP的N2潜伏期、P3潜伏期在三种不同言语、纯音刺激时的差异均具有统计学意义,其中以数字诱发的P3潜伏期最长,而右耳记录到的AERP各参数在不同刺激声诱发时均无明显差异； 6、无论是言语刺激声还是纯音刺激声,左侧大脑半球在言语处理过程中均处于优势地位,但是并不是绝对和唯一的优势半球。左右半球在言语处理过程中是相互协调、相互补偿的。
[Abstract]:objective
1, the auditory event related potential (auditory event-related potentials, AERP) was induced by different stimuli (including pure tone, real word, double syllable word and number) to explore the feasibility of different forms of Chinese language sound stimulation to test the Chinese AERP.
2, comparing pure tone and three different Chinese speech stimuli to induce AERP waveform at the optimum intensity, analyze the difference of P3 latency and amplitude in each waveform, and quantify the AERP waveform, and discuss the relationship between the stimulus sound and the AERP waveform.
3, compare the difference of AERP waveform in single ear induced by different speech stimuli, analyze the characteristics of speech dominant hemisphere and further explore the relationship between the left and right hemispheres and the different speech processing.
Method
According to the characteristics of Chinese language, speech audiometry and AERP test sound stimulation, Chinese monosyllabic words, double syllable words and digital tables are selected for speech test signals that are compatible with AERP testing software by stereo recording, editing, conversion and editing, and the target stimuli and non target stimuli are randomly selected, and the test intensity (sensory level) is set to 60dB SL. used different Chinese language (including real words, double syllable words and numbers) and pure tone as sound stimulation to test 37 normal young people (70 ears). The AERP waveform of each group was marked and quantified. The latent period, amplitude and waveform score of the AERP were compared between the speech and the pure tone stimuli. The differences in the effects of different acoustic stimuli on P300 are also found between the left and right ears, and the difference in the left and right ears of the AERP waves induced by the pure tone and the three different Chinese speech stimuli at the optimum intensity is further discussed and the relationship between the left and right hemisphere and the different speech processing processes is further explored.
Result
Different Chinese language and pure tone can record a typical AERP waveform, and there is a significant difference in the P3 extraction rate between each group (X2=9.046, P=0.029). Among them, the double syllable word stimulus is the most easy to record, the extraction rate is 98.6%, and the difference between the pure tone group and the pure tone group has the statistical significance (X2=7.992, P=0.0050.05/6,6 is the comparison number). There was no significant difference in AERP extraction rate between other groups (P value was 0.05). There was no significant difference in the difference of P3 waveform and N2-P3 amplitude between different stimuli (the former F=1.795, P=0.496; the latter F=0.800, P=0.496), but from the overall point of view, the AERP waveforms induced by words and double syllables were more smooth and less clutter than those of digital and pure tones. The average latency of P3 between different stimuli groups was significantly different (F=5.088, P=0.005). The latency of P3 induced by digital group was the longest, and the difference between the other three groups was statistically significant (P value was 0.05), while the P3 latency of other groups was not significantly different (P value was 0.05). Both ears were recorded for four different stimuli. The N2 latency, P3 latency and N2-P3 amplitude in the typical AERP waveforms were compared with single ear, and the average latency of N2 and P3 in the left ear was found to be significantly different between different groups (the former F=3.489, P=0.020; the latter F=8.343, P=0.000). The right ear N2, the P3 average latency was not statistically significant between the four groups. 0, the latter F=0.323, P=0.808), there was no significant difference in amplitude of N2-P3 between different groups (left ear F=1.690, P=0.177; right ear F=1.644, P=0.187).
conclusion
1, in addition to pure tone and word, other forms of Chinese speech, such as double syllable words, are also applicable to the requirements of AERP test stimulus sound, and can get a satisfactory AERP waveform. It is also suitable for the AERP test of Chinese people. It provides a more practical test for the further popularization of the speech test AERP for the Chinese people. Law;
2, at the best test intensity, the speech stimulus is more easily recorded than the pure tone in the typical AERP waveform, in which the double syllable words with the stimulus sound are more easily recorded than the pure tone.
3, from all the data and waveforms, we can see that the AERP waveform induced by the stimulus and double syllable words is more smooth than the number and pure tone, and the clutter is less and the waveform is more typical.
4, the effect of stimulus content on the latency of P300 was statistically significant, and the latency of digital P3 was significantly longer than that of the other groups, but there was no significant effect on the P300 amplitude.
5, the N2 latency of AERP recorded by the left ear, the P3 latency in three different languages, the differences of pure tone stimulation were statistically significant, and the latency of P3 induced by digital was the longest, and the AERP parameters recorded in the right ear were not significantly different when the stimuli were induced by different stimuli.
6, both verbal and pure tone stimulation, the left hemisphere is dominant in the process of speech processing, but it is not the absolute and unique dominant hemisphere. The left and right hemispheres coordinate and compensate each other in the process of speech processing.

【学位授予单位】：南方医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R764

【参考文献】