全聋型突发性耳聋临床预后分析

发布时间：2018-04-27 13:32

  本文选题：聋 + 突发性　； 参考：《中国耳鼻咽喉颅底外科杂志》2016年01期

【摘要】：目的探讨全聋型突发性耳聋的临床预后情况。方法采用回顾性研究纳入年龄21~70岁,病程在1周内的全聋型突发性耳聋患者(纯音测听全部频率听阈升高,0.5、1、2、4kHz平均听阈≥81 dBHL)。采用统一治疗方案,前列地尔注射液+舒血宁+腺苷钻胺+激素和高压氧治疗。将不同治疗时间、不同频率听力改善情况进行统计分析。结果全聋型突发性耳聋患者52例,其中男22例(42.31%),女30例(57.69%),连续用药1周、2周和3周总有效率分别为38.46%、57.69%、65.38%,组间听力改善总有效率差异有统计学意义(χ~2=8.048,P=0.018)。第2周和第3周总有效率比较,差异不具有统计学意义(χ~2=0.650,P=0.420)。第2周和第3周治愈率比较,差异具有统计学意义(χ~2=0.865,P=0.451)。第2周和第3周总显效性比较,差异具有统计学意义(χ~2=3.544,P=0.1622)。治疗3周后备频率听力恢复情况比较,不同频率间痊愈率差异具有统计学意义(χ~2=4.590,P=0.032),其中低频0.25 kHz痊愈率为46.16%,0.5 kHz痊愈率为34.61%,明显高于其它频率。不同频率间总显效率比较,差异具有统计学意义(χ~2=33.243,P0.001)。不同频率间总有效率比较,差异具有统计学意义(χ~2=16.008,P0.001),其中0.25、0.5 kHz总有效率均为78.85%。经过3周治疗后,不伴有眩晕的极重度聋患者总有效率为77.78%,痊愈率为26.92%,伴有眩晕的极重聋患者总有效率为52%,痊愈率为12%,两组总有效率比较,差异不具有统计学意义(χ~2=3.811,P=0.051);但两组痊愈率比较,差异具有统计学意义(χ~2=0.005,P=0.0000)。结论全聋型突发性耳聋患者连续治疗3周可明显改善患者听力,且低频区听力恢复要好于高频区。不伴有眩晕全聋型突发性耳聋患者痊愈率要高于伴有眩晕的全聋型突发性耳聋患者。
[Abstract]:Objective to investigate the clinical prognosis of sudden deafness with total deafness. Methods A retrospective study was carried out in 21 to 70 years old patients with sudden deafness with a course of 1 week. A unified treatment scheme was used, and alprostadil injection was treated with Shuxuening adenosine diamine hormone and hyperbaric oxygen. The improvement of hearing at different time and frequency was analyzed statistically. Results there were 52 cases of sudden deafness with total deafness, of which 22 cases were male (42.31) and 30 female (57.69%). The total effective rates were 38.46% for 2 weeks and 65.38% for 3 weeks, respectively. There was significant difference in the total effective rate of hearing improvement between the two groups (蠂 ~ 28.048) (P = 0.018). There was no significant difference in the total effective rate between the 2nd week and the 3rd week (蠂 2 + 0.650 P 0. 420). The difference between the cure rate at the 2nd week and the 3rd week was statistically significant (蠂 ~ 2 / 0 ~ (865) P ~ (0.451)). There was significant difference in the total effect between the second week and the third week (蠂 ~ 2 / 3.544 ~ 0.1622). There was significant difference in recovery rate between different frequencies (蠂 ~ (2 / 2) 4.590), in which the recovery rate of low frequency 0.25 kHz was 46.16 ~ (0.5) kHz, which was significantly higher than that of other frequencies. There was significant difference in the total effective rate among different frequencies (蠂 ~ (2 +) ~ (33) 243) P 0.001 ~ (-1). There was significant difference in the total effective rate between different frequencies (蠂 ~ (2 +)) (蠂 ~ (2 +)) ~ (16.008) (P _ (0.001)), in which the total effective rate of 0.25 ~ (0.5) kHz was 78.85. After 3 weeks of treatment, the total effective rate of extremely severe deafness without vertigo was 77.78, and the cure rate was 26.92. The total effective rate of the patients with dizziness was 52 and the cure rate was 12. The total effective rate of the two groups was compared. The difference was not statistically significant (蠂 ~ 2 + 3.811), but the difference between the two groups was statistically significant (蠂 ~ (2 / 2) 0.005 / P ~ (0.000)). Conclusion the hearing of patients with sudden deafness can be improved after 3 weeks of continuous treatment, and the recovery of hearing in the low frequency region is better than that in the high frequency region. The recovery rate of sudden deafness without vertigo was higher than that without vertigo.
【作者单位】： 北京市海淀医院北京大学第三医院海淀院区耳鼻咽喉科;
【分类号】：R764.437
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本文编号：1810932