慢性闭角型青光眼患者房水中炎症因子浓度升高

发布时间：2018-04-28 03:28

本文选题：青光眼 + 房水　；参考：《眼科》2017年04期

【摘要】：目的比较急、慢性原发性闭角型青光眼与老年性白内障患者房水中多种炎症因子浓度的差异。设计实验研究。研究对象连续的16例急性闭角型青光眼患者、16例慢性闭角型青光眼患者、22例老年性白内障患者的房水。方法使用悬浮液相芯片技术同时检测房水中多种细胞因子浓度,比较不同组之间的差异,并进行细胞因子间相关性分析。显著水准0.0167。主要指标房水中粒细胞集落刺激因子(G-CSF)、干扰素-γ(IFN-γ)、白介素-6(IL-6)、白介素-8(IL-8)、单核细胞趋化蛋白-1(MCP-1),血小板衍生生长因子-AA(PDGF-AA)、血小板衍生生长因子-AB(PDGF-AB)、趋化因子配体5(RANTES)、肿瘤坏死因子-α(NF-α)的浓度。结果急性闭角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8、MCP-1、RANTES和TNF-α浓度均显著高于白内障组(P均0.0167),慢性闭角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8和MCP-1浓度显著高于白内障组(P均0.0167),急性和慢性闭角型青光眼房水中各炎症因子浓度均无统计学差异(P均0.0167)。结论除了急性闭角型青光眼外,慢性闭角型青光眼眼前节也存在炎症反应。
[Abstract]:Objective to compare the concentration of multiple inflammatory factors in aqueous humor of patients with acute, chronic primary angle closure glaucoma and senile cataract. Design experimental research. Participants Sixteen consecutive patients with acute angle-closure glaucoma 16 patients with chronic angle-closure glaucoma and 22 patients with senile cataract had aqueous humor. Methods the concentration of cytokines in aqueous humor was detected simultaneously by suspension liquid chip technique. The differences among different groups were compared and the correlation between cytokines was analyzed. Significant level 0.0167. Main outcome measures concentration of granulocyte colony stimulating factor G-CSFN, IFN- 纬 -interferon- 纬, interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemotactic protein (MCP-1), platelet-derived growth factor (AAAN) PDGF-AAN, platelet-derived growth factor-ABPDGF-ABN, chemokine ligand 5ARANTESU, tumor necrosis factor- 伪 NF- 伪 in aqueous humor. Results the concentrations of G-CSFU PDGF-AAIL-6 IL-8 and TNF- 伪 in aqueous humor of patients with acute angle-closure glaucoma were significantly higher than those in cataract group (P = 0.0167), and those in aqueous humor of patients with chronic angle-closure glaucoma were significantly higher than those in cataract group (P = 0.0167). There was no statistical difference in the concentration of inflammatory factors in aqueous humor of light eyes (P = 0.0167). Conclusion in addition to acute angle-closure glaucoma, there are inflammatory reactions in the anterior segment of chronic angle-closure glaucoma.
【作者单位】：第三军医大学大坪医院野战外科研究所眼科重庆市眼科学重点实验室;
【分类号】：R775.2;R776.1

【相似文献】