持续气道正压通气治疗对中重度OSAHS患者血清pentraxin-3水平的影响
发布时间:2018-04-29 20:29
本文选题:阻塞性睡眠呼吸暂停低通气综合征 + 持续气道正压通气 ; 参考:《山东医药》2017年05期
【摘要】:目的探讨持续气道正压通气(CPAP)治疗对中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清正五聚蛋白3(pentraxin-3)水平的影响。方法选择112例患者,根据呼吸暂停低通气指数(AHI)分为单纯打鼾(AHI5)组32例、轻度OSAHS(AHI 5~20)组35例、中重度OSAHS(AHI≥21)组45例。同期选择体检健康者30例为正常对照组。中重度OSAHS组行基础治疗与CPAP治疗,时间6个月。采用爱普沃斯困倦量表(ESS)评分评价患者主观嗜睡程度,多导睡眠图(PSG)检测AHI、最低血氧饱和度(LSa O2),酶联免疫吸附法检测血清pentraxin-3,动脉硬化检测仪检测肱踝动脉脉搏波传导速度(ba PWV);用Spearman相关分析血清pentraxin-3与其余指标的关系。结果中重度OSAHS组血清pentraxin-3水平、ba PWV高于轻度OSAHS组、单纯打鼾组、正常对照组(P均0.05)。与治疗前比较,治疗后中重度OSAHS组血清pentraxin-3、ESS评分、AHI及ba PWV下降,LSa O2升高(P均0.05)。中重度OSAHS组治疗前后血清pentraxin-3水平与ESS评分、AHI及ba PWV呈正相关(P均0.05),与LSa O2、CPAP应用时间呈负相关(P均0.05)。结论 CPAP治疗能降低中重度OSAHS患者血清pentraxin-3水平。
[Abstract]:Objective to investigate the effect of CPAP on serum pentraxin-3 in patients with moderate and severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 112 patients were divided into three groups according to apnea hypopnea index (AHI): 32 cases of simple snoring group, 35 cases of mild OSAHS(AHI group and 45 cases of moderate and severe OSAHS(AHI 鈮,
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