GLUT-1和MCT-4与CAⅨ在喉鳞状细胞癌中的初步研究

发布时间：2018-04-30 12:36

  本文选题：葡萄糖转运体 + 单羧酸转运体　； 参考：《临床耳鼻咽喉头颈外科杂志》2017年07期

【摘要】：目的:本文旨在评估与代谢相关的葡萄糖转运体1(GLUT-1)、单羧酸转运体4(MCT-4)和碳酸酐酶9(CAⅨ)在喉鳞状细胞癌中的表达及临床意义。方法:收集经手术切除的40例喉鳞状细胞癌组织及10例癌旁组织,并对临床资料进行整理分析。应用免疫组织化学方法检测GLUT-1、MCT-4与CAⅨ在40例喉鳞状细胞癌和10例癌旁组织中的表达情况,评估它们与临床病理学资料的关系。所有数据采用SPSS21.0统计学软件进行分析。结果:在40例喉鳞状细胞癌组织中GLUT-1、MCT-4和CAⅨ的阳性表达率分别为72.5%、75.0%和55.0%。其中,MCT-4在正常组织中表达较低或几乎不表达,而GLUT-1在正常组织中具有干细胞活性的基底细胞层高表达。GLUT-1、MCT-4和CAⅨ的阳性表达与病理分级密切相关(均P0.05),其中低分化的喉鳞状细胞癌中的阳性表达率远高于高分化组。此外,在40例喉鳞状细胞癌组织中MCT-4和CAⅨ的阳性表达和TNM分期相关,差异有统计学意义(均P0.05)。MCT-4和CAⅨ在Ⅲ~Ⅳ期的表达率远高于Ⅰ~Ⅱ期。GLUT-1、MCT-4和CAⅨ的表达与患者的年龄、吸烟量及有无淋巴结转移及肿瘤的位置无关(P0.05),GLUT-1、MCT-4和CAⅨ呈正相关。结论:葡萄糖摄取与酸性微环境在喉鳞状细胞癌代谢重塑和肿瘤的侵袭及演进密切相关,因此,在缺氧的微环境下靶向与代谢相关的蛋白质或许是治疗侵袭性肿瘤的有效策略。
[Abstract]:Objective: to evaluate the expression and clinical significance of glucose transporter (GLUT-1), monocarboxylic acid transporter (MCT-4) and carbonic anhydrase (9(CA IX) in laryngeal squamous cell carcinoma (LSCC). Methods: 40 cases of laryngeal squamous cell carcinoma and 10 cases of adjacent tissues were collected and analyzed. The expression of GLUT-1 MCT-4 and CA IX in 40 cases of laryngeal squamous cell carcinoma (LSCC) and 10 cases of paracancerous tissues were detected by immunohistochemical method, and the relationship between them and clinicopathological data was evaluated. All the data were analyzed by SPSS21.0 statistical software. Results: in 40 cases of laryngeal squamous cell carcinoma, the positive rates of GLUT-1, MCT-4 and CA IX were 72.5% and 55.0%, respectively. The expression of MCT-4 in normal tissues was low or almost non-expressed. However, the positive expression of GLUT-1 in the basal cell layer with stem cell activity. GLUT-1, MCT-4 and CA IX were closely related to the pathological grade (P0.05), and the positive expression rate in poorly differentiated laryngeal squamous cell carcinoma was much higher than that in well-differentiated laryngeal squamous cell carcinoma. In addition, the positive expression of MCT-4 and CA IX in 40 cases of laryngeal squamous cell carcinoma was correlated with the stage of TNM, and the difference was statistically significant (the expression rates of P0.05).MCT-4 and CA IX in stage 鈪，

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