氯雷他定口服联合生理性海水鼻腔冲洗治疗间歇性变应性鼻炎的临床研究

发布时间：2018-05-03 09:11

本文选题：氯雷他定 + 生理性海水　；参考：《中国药房》2017年14期

【摘要】：目的:探讨氯雷他定口服联合生理性海水鼻腔冲洗治疗间歇性变应性鼻炎(AR)的临床效果及安全性。方法:选取河北医科大学第二医院2013年1月-2015年6月收治的间歇性AR患者共300例,按抽签法分为A、B、C组,各100例。A组患者给予氯雷他定片10 mg,po,qd;B组患者采用生理性海水鼻腔喷雾器进行鼻腔冲洗,早晚各冲洗1次;C组患者给予氯雷他定口服联合生理性海水鼻腔冲洗。3组患者疗程均为28 d。比较3组患者的临床疗效,治疗前后症状体征积分、呼吸功能指标和炎症因子指标水平,以及随访12个月期间的临床复发情况。结果:A、B、C组患者的总有效率分别为80.00%、78.00%、96.00%,C组显著高于A、B组,差异均有统计学意义(P0.05)。治疗前,3组患者的症状体征积分、呼吸功能指标和炎症因子水平比较,差异均无统计学意义(P0.05);治疗后,3组患者的症状体征积分、最大呼气流速(PEF)昼夜变异率、肿瘤坏死因子α、γ干扰素和白细胞介素(IL)-4水平均显著低于治疗前,PEF和IL-12水平均显著高于治疗前,且C组患者各指标水平均显著优于A、B组,差异均有统计学意义(P0.05)。A、B、C组患者的临床复发率分别为21.00%、23.00%、6.00%,C组显著低于A、B组,差异均有统计学意义(P0.05)。A、B组患者上述所有指标比较,差异均无统计学意义(P0.05)。结论:氯雷他定口服联合生理性海水鼻腔冲洗治疗间歇性AR可有效减轻患者鼻部症状体征,改善患者呼气功能,下调机体炎症反应水平,并有助于降低远期复发风险。
[Abstract]:Objective: to investigate the clinical efficacy and safety of oral loratadine combined with physiologic sea water nasal irrigation in the treatment of intermittent allergic rhinitis (ARL). Methods: a total of 300 intermittent AR patients treated in the second Hospital of Hebei Medical University from January 2013 to June 2015 were selected and divided into two groups according to the drawing of lots. One hundred patients in group A were treated with loratadine 10 mg / kg poqdtadine B group, and the patients in group B were treated with a physiological seawater nasal spray apparatus for nasal cavity irrigation. The course of treatment in group C was 28 days after oral administration of loratadine and physiologic nasal cavity irrigation. The clinical efficacy, the score of symptoms and signs, the index of respiratory function and inflammatory factors before and after treatment were compared among the three groups, and the clinical recurrence during the 12 months follow-up was compared. Results the total effective rate of group C was 80.000.The total effective rate of group C was significantly higher than that of group A B, and the difference was statistically significant (P 0.05). Before treatment, there was no significant difference in the scores of symptoms and signs, respiratory function index and inflammatory factor level between the three groups, and the diurnal variation rate of symptom and sign score, maximum expiratory flow rate (PEF), and the level of inflammatory factors in the three groups were not significantly different before and after treatment. The levels of tumor necrosis factor 伪, interferon 纬 and interleukin-4 were significantly lower than those before treatment and the levels of IL-12 were significantly higher in group C than those in group A and B, and the levels of each index in group C were significantly higher than those in group A and B. There were significant differences in the clinical recurrence rate of patients in group C (P 0.05) and group A (P 0.05). The clinical recurrence rate of group C was 21.000.23.00 and the value of group C was significantly lower than that of group A and B, and the difference was statistically significant (P 0.05). There was no significant difference in all the above indexes in group A (P 0.05) and group A (P 0.05), and there was no significant difference (P 0.05) between group C and group A (P 0.05). Conclusion: oral loratadine combined with physiologic sea water nasal irrigation can effectively reduce nasal symptoms and signs, improve expiratory function, down-regulate the level of inflammation, and help to reduce the long-term risk of recurrence.
【作者单位】：河北医科大学第二医院耳鼻咽喉二科;石家庄市鹿泉人民医院儿科;石家庄市第三医院耳鼻咽喉科;石家庄市第一医院耳鼻咽喉科;
【分类号】：R765.21

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