变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的临床对照研究

发布时间：2018-05-03 21:29

本文选题：丙酸氟替卡松 + 变应性鼻炎　；参考：《中国药师》2016年04期

【摘要】：目的:研究变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的有效性和安全性。方法:选择变应性鼻炎伴腺样体生长的患儿160例做为观察组,其中腺样体肥大者109例;选择同期单纯腺样体生长的患儿157例做为对照组,其中腺样体肥大者114例。两组患儿均接受丙酸氟替卡松喷剂治疗3个月。观察比较两组患儿治疗前后鼻镜下腺样体体积、症状评分变化,以及药品不良反应发生情况。结果:变应性鼻炎伴随腺样体肥大患儿多发于3~6岁。治疗后,观察组有效腺样体缩小患者88例(80.73%),显著多于对照组的67例(58.77%)(P0.01);对照组治疗后腺样体肥大的患者为55例(35.03%),明显多于观察组的44例(68.13%,P0.05)。治疗前后观察组患者的鼻塞症状积分差值、打鼾症状积分差值、张口呼吸症状积分差值显著大于对照组(P0.05)。结论:丙酸氟替卡松喷剂对于缩小变应性鼻炎伴腺样体肥大患儿腺样体体积比单纯腺样体肥大患儿更明显,且能更显著改善打鼾、鼻塞、张口呼吸症状。
[Abstract]:Objective: To study the efficacy and safety of the use of fluticasone propionate spray in children with allergic rhinitis and adenoid hypertrophy. Methods: 160 children with allergic rhinitis with adenoid growth were selected as observation group, of which 109 cases were adenoid hypertrophy, and 157 children with adenoid growth were selected as control group, in which adenoid samples were selected. There were 114 cases of hypertrophy of body. The two groups were treated with fluticasone propionate for 3 months. The volume of adenoid body under the nasal mirror, the symptom score change, and the adverse drug reaction were observed and compared before and after treatment in the two groups. Results: the allergic rhinitis accompanied with adenoid hypertrophy was 3~6 years old. After treatment, the observation group was effective adenoid contraction. 88 cases of small patients (80.73%) were significantly more than 67 cases (58.77%) in the control group (P0.01), and 55 cases (35.03%) of adenoid hypertrophy in the control group were more than 44 cases (68.13%, P0.05) in the observation group. The difference value of nasal congestion symptom score, the integral difference of snoring symptoms and the score difference of mouth breathing symptoms were significantly greater than those of the control group before and after treatment. Group (P0.05). Conclusion: the fluticasone propionate spray is more obvious in reducing the volume of adenoid hypertrophy in children with allergic rhinitis and adenoid hypertrophy, and can improve snoring, nasal congestion and mouth breathing.

【作者单位】：襄阳市中心医院耳鼻咽喉—头颈外科;
【分类号】：R765.21;R766

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