周边部视网膜格子样变性区自发荧光特征的研究

发布时间：2018-05-05 14:41

本文选题：自发荧光 + 周边部　；参考：《山西医科大学》2012年硕士论文

【摘要】：目的观察周边部视网膜格子样变性区的脂褐质相关自发荧光(FAF)和黑色素相关自发荧光(NIA)特征,通过FAF和NIA研究格子样变性区视网膜功能与代谢的改变。方法50例视网膜格子样变性患者68只眼纳入本研究。所有患者均经裂隙灯前置镜眼底检查及欧堡全景眼底照相系统(Optomap200)确诊。应用共焦激光眼底血管造影仪HRA2(海德堡视网膜脉络膜眼底造影系统)行脂褐质相关自发荧光(FAF)及黑色素相关近红外光自发荧光(NIA)检查。通过将格子样变性区与周围正常视网膜组织的自发荧光(AF)强度进行比较,把AF强度分级为强荧光、正常荧光、弱荧光和无荧光。对照眼底全景照相结果归纳总结视网膜格子样变性的FAF及NIA特征,并将这两种AF表现特征进行对比分析。结果68只眼中,FAF显示有异常荧光表现有68只眼,占100%。表现为与格子样变性区形态一致的边界清晰的强荧光者12只眼,占17.6%；表现为与格子样变性区形态一致的边界清晰的强荧光中间杂斑片状弱荧光及无荧光者56只眼,占82.4%。NIA显示有异常荧光表现有57只眼,占83.8%。表现为大致正常荧光者11只眼,占16.2%；表现为与格子样变性区形态一致的边界尚清的稍强荧光中间杂斑片状弱荧光及无荧光者16只眼,占23.5%；表现为边界不清的稍强荧光中间杂斑片状弱荧光或无荧光者41只眼,占60.3%。两种自发荧光对比分析显示：FAF所示强荧光强度比NIA更强；FAF与NIA所示斑片状弱荧光位置及大小一致；FAF所示格子样变性区的边界较NIA更为清晰。结论HRA2可清晰获取周边部视网膜格子样变性区自发荧光图像。视网膜格子样变性区有其特征性的自发荧光表现。格子样变性与RPE细胞内脂褐质的积聚有关,与RPE细胞内黑色素之间的关系不明显。
[Abstract]:Objective to observe the characteristics of lipofuscin associated autofluorescence (FAF) and melanin-associated autofluorescence (NIA) in the latticular degeneration of the peripheral retina, and to investigate the changes of retinal function and metabolism by FAF and NIA. Methods Sixty-eight eyes of 50 patients with retinal lattice degeneration were included in this study. All patients were diagnosed by slit lamp anterior ophthalmoscopy and Optomap200 panoramic fundus photography system. HRA2 (Heidelberg Retinal choroidal fundus Angiography system) was used to detect lipofuscin associated autofluorescence (FAF) and melanin related near infrared autofluorescence (NIAA). The intensity of AF was classified as strong fluorescence, normal fluorescence, weak fluorescence and no fluorescence by comparing the AFI intensity of the lattice denatured area with that of the surrounding normal retina. The FAF and NIA features of retinal latticular degeneration were summarized and compared with the results of panoramic radiography. Results 68 eyes showed abnormal fluorescence in 68 eyes, accounting for 100%. There were 12 eyes (17.6 eyes) with strong fluorescence with clear boundary consistent with the shape of the lattice denatured area, 56 eyes with weak and non-fluorescent heteroplakia with clear boundary and clear boundary with the shape of the denatured area. 82.4%.NIA showed abnormal fluorescence in 57 eyes (83.8%). There were 11 eyes with approximately normal fluorescence, accounting for 16.2%, and 16 eyes with slight strong fluorescence with clear boundary and 16 eyes with no fluorescence. There were 41 eyes (60.3%) with weak or no fluorescence in the middle of slightly strong fluorescence with unclear boundary. The contrast analysis of two kinds of autofluorescence shows that the strong fluorescence intensity of NIA is stronger than that of NIA, and the boundary of the lattice denatured region shown by FFAF is more clear than that of NIA. Conclusion HRA2 can obtain the autofluorescence images of the peripheral retinal lattice degeneration clearly. The latticular degeneration of the retina has its characteristic autofluorescence features. Lattice degeneration was related to the accumulation of lipofuscin in RPE cells, but not to melanin in RPE cells.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R774.1

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