舌下脱敏治疗儿童间歇性变应性鼻炎、过敏性哮喘50例疗效分析

发布时间：2018-05-06 21:14

本文选题：舌下脱敏治疗 + 粉尘螨滴剂　；参考：《儿科药学杂志》2016年01期

【摘要】：目的:评估舌下含服粉尘螨滴剂治疗尘螨致敏的间歇性过敏性哮喘、变应性鼻炎患儿的临床疗效;观察单一脱敏对单一粉尘螨过敏和双螨过敏的疗效。方法:收集2012年6月至2013年6月我院儿科确诊的尘螨过敏间歇性变应性鼻炎(AR)和过敏性哮喘(AS)患儿50例,按皮肤点刺试验(SPT)结果将患儿分为粉尘螨组27例和双螨组23例。记录所有患儿治疗前和治疗12个月后的症状评分、用药情况评分和视觉模拟(VAS)评分。采用酶联免疫吸附(ELISA)法检测部分患儿的血清特异性免疫球蛋白G亚型4(s Ig G4)水平。结果:(1)舌下脱敏治疗12个月后,患儿的症状评分、用药评分和VAS评分均有显著降低,和舌下脱敏治疗前比较差异有统计学意义(P0.01);患儿的血清s Ig G4水平脱敏治疗前为61.78(9.87,131.18),脱敏治疗12个月后为133.99(67.28,166.63),治疗前后比较差异具有统计学意义(P0.01)。(2)单一粉尘螨舌下脱敏治疗单一粉尘螨和双螨过敏患儿12个月后,患儿的症状评分、用药评分和VAS评分均显著性降低,且和治疗前相比差异具有统计学意义(P0.01);治疗12个月后,粉尘螨组和双螨组的症状评分和VAS评分比较差异无统计学意义(P0.05)。结论:舌下脱敏治疗尘螨过敏引起的间歇性哮喘鼻炎患儿具有显著效果,单一粉尘螨脱敏治疗单一粉尘螨过敏和双螨过敏患儿的疗效相当。
[Abstract]:Objective: to evaluate the clinical efficacy of sublingual dust mites drops in the treatment of allergic asthma and allergic rhinitis caused by dust mite, and to observe the efficacy of desensitization to single dermatophagoides farinae allergy and double mite allergy. Methods: from June 2012 to June 2013, 50 children with allergic intermittent allergic rhinitis (ARA) and allergic asthma (ASA) diagnosed in our hospital were divided into two groups: dust mite group (n = 27) and double mite group (n = 23) according to the results of skin prick test (SPT). Symptom scores, medication scores and visual analogue vas scores were recorded before and 12 months after treatment. The level of serum specific immunoglobulin G subtype 4 G was detected by Elisa. Results after 12 months of sublingual desensitization, the symptom score, drug use score and VAS score of the children decreased significantly. The serum level of sIGG4 was 61.78g G4 before desensitization and 133.99m 67.28166.63m after 12 months of desensitization. The difference between before and after treatment was statistically significant (P0.01. 2). After 12 months of sensitive treatment for children with single dust mite and double mite allergy, The symptom score, drug use score and VAS score of the children were significantly lower than those before treatment (P 0.01), but after 12 months of treatment, there was no significant difference in symptom score and VAS score between the dust mite group and the double mite group. Conclusion: sublingual desensitization is effective in treating intermittent asthma rhinitis caused by dust mite allergy.
【作者单位】：浙江省舟山市普陀中医院;温州医科大学附属第一医院;温州医科大学附属第二医院育英儿童医院;
【分类号】：R765.21;R725.6

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