益气解毒方抗单纯疱疹病毒性角膜炎复发的临床研究

发布时间：2018-05-07 18:08

本文选题：益气解毒方 + 单纯疱疹病毒性角膜炎　；参考：《青海大学》2012年硕士论文

【摘要】：目的：探讨中药益气解毒方抗单纯疱疹病毒性角膜炎（herpes simplex keratitis，HSK）复发的临床疗效。方法：将诊断为复发性HSK患者随机分为对照组和治疗组,各组均为80只眼，对照组给予更昔洛韦眼用凝胶点眼，治疗组在更昔洛韦眼用凝胶点眼，同时给予益气解毒汤口服，治疗两疗程（30天），并对治愈后患者随访1年，其中治疗组78只眼，对照组79只眼。结果：治疗组浅层型角膜炎的总有效率为92.5%，经统计学分析，两组有显著性差异（P0.05），治疗组深层型角膜炎的总有效率为89.5%，经统计学分析，两组有显著性差异（P0.05），治疗组浅层型平均治愈时间为12.23±2.06天，明显较对照组缩短（P0.01），深层型平均治愈时间为19.67±3.12天，明显较对照组缩短（P0.01）。随访结果显示，第一周期治疗组74例中7例复发，复发率为9.5%，对照组72例中20例复发，复发率为27.8%，第二周期治疗组65例中8例复发，复发率为12.3%；对照组50例中18例复发，复发率为36%。两周期内治疗组的复发率均明显低于对照组（P0.01）。两组治愈患者第一次复发平均时间比较，治疗组较对照组延长，经统计学处理，差异有显著性（P0.05）。两组治疗前后平均1年内的复发次数比较，，治疗组治疗后较治疗前明显减少（P0.01），对照组则无明显变化（P0.05）。结论：中药益气解毒方治疗复发性HSK，可提高疗效，缩短病程，延长潜伏时间，减少复发次数降低复发率，具有明显增加抗单纯疱疹病毒和抗HSK复发的功效。
[Abstract]:Objective: to investigate the clinical effect of Yiqi jiedu recipe (YQJD) on the recurrence of herpes simplex keratitis. Methods: the patients with recurrent HSK were randomly divided into control group and treatment group, each group was 80 eyes. The control group was given ganciclovir eye gel point eye, the treatment group was treated with ganciclovir eye gel point eye, and the treatment group was given Yiqi jiedu decoction orally. The patients were followed up for 1 year, 78 eyes in the treatment group and 79 eyes in the control group. Results: the total effective rate of superficial keratitis in treatment group was 92.5. There was a significant difference between the two groups by statistical analysis, and the total effective rate of deep keratitis in treatment group was 89.5g by statistical analysis. There was significant difference between the two groups (P 0.05). The average cure time of the superficial type in the treatment group was 12.23 卤2.06 days, which was significantly shorter than that in the control group (P 0.01), and the average cure time in the deep type was 19.67 卤3.12 days, which was significantly shorter than that in the control group. The follow-up results showed that in the first cycle treatment group, 7 cases recurred with a recurrence rate of 9.5%, 20 cases in the control group with a recurrence rate of 27.8 cases, 8 cases in the second cycle treatment group with a recurrence rate of 12.3% and 18 cases in the control group of 50 cases. The recurrence rate was 36%. The recurrence rate in the treatment group was significantly lower than that in the control group (P 0.01). The average time of the first relapse in the two groups was longer than that in the control group, and the difference was statistically significant (P 0.05). The average recurrence times of the two groups within 1 year before and after treatment were significantly decreased after treatment in the treatment group than before treatment, but no significant change was found in the control group. Conclusion: Yiqi jiedu prescription can improve the curative effect, shorten the course of disease, prolong the latent time, reduce the times of recurrence and reduce the recurrence rate. It can obviously increase the effect of anti-herpes simplex virus and anti-recurrence of HSK.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R772.21

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