宁夏地区回汉人群变应性鼻炎患者血清中IL-4浓度与微量元素水平的相关性研究

发布时间：2018-05-09 04:21

本文选题：微量元素 + IL-　；参考：《临床耳鼻咽喉头颈外科杂志》2016年09期

【摘要】：目的:研究宁夏地区回汉人群变应性鼻炎(AR)患者血清中微量元素与IL-4浓度的相关性。方法:以260例AR患者为AR组(回族130例,汉族130例);设正常对照组260例(回族130例,汉族130例)。采用ELISA法和电感耦合等离子体原子发射光谱法(ICP-AES)分别检测520例样本血清中IL-4的浓度及Fe、Zn、Mn、Ni、Se的含量,并分析回汉人群AR患者微量元素水平与IL-4之间的相关性。结果:1回族和汉族AR患者血清IL-4的含量均高于对照组(P0.05);2回族AR患者血清Zn、Se的含量低于对照组,Ni高于对照组(P0.05);汉族AR患者Zn低于对照组,Ni含量高于对照组(P0.05);3AR组血清IL-4水平与Ni值呈正相关(r=0.671,P0.01);IL-4水平与Zn值呈负相关(r=-0.819,P0.01)。结论:宁夏地区回汉人群AR患者血清中IL-4浓度与Zn、Ni的浓度存在显著的相关关系,微量元素参与AR的发生和发展,为AR的诊断及治疗提供了重要依据。
[Abstract]:Objective: to study the correlation between serum trace elements and IL-4 concentration in patients with allergic rhinitis in Hui Han population of Ningxia. Methods: 260 AR patients were selected as AR group (130 Hui and 130 Han) and 260 normal controls (130 Hui and 130 Han). ELISA and ICP-AESs were used to detect the concentration of IL-4 in serum and the content of Fe ~ (2 +) Zn ~ (2 +) mn ~ (2 +) NiSe in 520 samples, respectively, and the correlation between trace element level and IL-4 in AR patients of Huihan population was analyzed. Results the content of IL-4 in AR patients of Hui nationality and Han nationality was higher than that of control group (P0.05), and the content of Zn in AR patients of Han nationality was lower than that of control group (P0.05) and that of control group was higher than that of control group (P0.05 ~ 3AR group), while the content of Zn in AR patients of Han nationality was lower than that of control group. The content of serum IL-4 in AR patients of Han nationality was higher than that in control group. The level of IL-4 was positively correlated with the value of Ni. There was a negative correlation between the level of IL-4 and the value of Zn. Conclusion: there is a significant correlation between the concentration of IL-4 in serum and the concentration of Ni in AR patients in Hui Han population in Ningxia. Trace elements are involved in the occurrence and development of AR, which provides an important basis for the diagnosis and treatment of AR.
【作者单位】：宁夏医科大学;宁夏医科大学总医院耳鼻咽喉头颈外科;银川市第三人民医院耳鼻咽喉头颈外科;
【分类号】：R765.21

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